L9668
Lidoflazine
≥98% (HPLC), powder
别名:
4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide
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关于此项目
经验公式（希尔记法）:
C30H35F2N3O
化学文摘社编号:
分子量:
491.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
222-312-8
MDL number:
InChI
1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
InChI key
ZBIAKUMOEKILTF-UHFFFAOYSA-N
SMILES string
Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM
HERG calcium channel blocker
Features and Benefits
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
W J Flameng et al.
The Annals of thoracic surgery, 61(2), 621-628 (1996-02-01)
Factors determining the outcome of operative correction of valvular abnormalities combined with coronary artery bypass grafting are still incompletely defined. Determinants of early and late (more than 90 days) deaths and event-free survival were studied for combined valve operations and
L Noyez et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 6(7), 377-381 (1992-01-01)
The concept of pretreatment of the myocardium with a pharmacological agent protecting the cell against ischemic and reperfusion injury is very attractive. Lidoflazine, a calcium overload blocker, predominantly membrane stabilizing, is able to prevent cell damage during ischemic arrest and
J Jacobsson et al.
Cryobiology, 29(3), 305-309 (1992-06-01)
The purpose of this study was to investigate the possibility of improving the organ preservation properties of the University of Wisconsin (UW) solution by adding the calcium entry blocker lidoflazine. We also investigated the possibility of decreasing the cold ischemia
John M Ridley et al.
Journal of molecular and cellular cardiology, 36(5), 701-705 (2004-05-12)
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. We investigated whether or not lidoflazine inhibits current through the rapid delayed rectifier K(+) channel alpha subunit (encoded by HERG -
P Vaagenes et al.
Resuscitation, 35(1), 41-52 (1997-08-01)
We explored the hypothesis that brain damage after cardiac arrest caused by ventricular fibrillation (VF) needs different therapies than that after asphyxiation, which has been studied less thoroughly. In 67 healthy mongrel dogs of both sexes cardiac arrest (at normothermia)
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