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L9668

Lidoflazine

Name: Lidoflazine
Brand: SIGMA

≥98% (HPLC), powder

别名:

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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关于此项目

经验公式（希尔记法）:

C₃₀H₃₅F₂N₃O

化学文摘社编号:

3416-26-0

分子量:

491.62

NACRES:

NA.77

PubChem Substance ID:

329817673

UNSPSC Code:

12352200

EC Number:

222-312-8

MDL number:

MFCD00057353

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChI key

ZBIAKUMOEKILTF-UHFFFAOYSA-N

说明

Biochem/physiol Actions

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC₅₀ < 0.1 μM

HERG calcium channel blocker

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.

A Chiarini et al.

Bioorganic & medicinal chemistry, 4(10), 1629-1635 (1996-10-01)

A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except for compounds 4b, 5a, and 5b, which exhibit

Pharmacotherapy for hypertension in adults 60 years or older.

Vijaya M Musini et al.

The Cochrane database of systematic reviews, 6, CD000028-CD000028 (2019-06-06)

This is the second substantive update of this review. It was originally published in 1998 and was previously updated in 2009. Elevated blood pressure (known as 'hypertension') increases with age - most rapidly over age 60. Systolic hypertension is more

Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects--a preliminary study.

P Vaagenes et al.

Resuscitation, 35(1), 41-52 (1997-08-01)

We explored the hypothesis that brain damage after cardiac arrest caused by ventricular fibrillation (VF) needs different therapies than that after asphyxiation, which has been studied less thoroughly. In 67 healthy mongrel dogs of both sexes cardiac arrest (at normothermia)

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全球贸易项目编号

货号	GTIN
L9668-5MG	04061833966877
L9668-25MG	04061832962108