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L9647

Sigma-Aldrich

柠檬苦素

from citrus seeds, >90% (HPLC)

别名:

吴茱萸碱, 柠檬苦素, 柠檬苦素酸 3,19:16,17 二内酯, 白藓脑内酯, 螺内酯

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About This Item

经验公式（希尔记法）:
C26H30O8
CAS号:
1180-71-8
分子量:
470.51
MDL编号:
MFCD00075922
UNSPSC代码:
12352205
PubChem化学物质编号:
24896458
NACRES:
NA.25
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生物来源

citrus seeds

质量水平

200

方案

>90% (HPLC)

表单

powder

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

2-8°C

SMILES字符串

CC1(C)O[C@H]2CC(=O)OC[C@]23[C@H]4CC[C@@]5(C)[C@@H](OC(=O)[C@H]6O[C@@]56[C@]4(C)C(=O)C[C@@H]13)c7ccoc7

InChI

1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1

InChI key

KBDSLGBFQAGHBE-MSGMIQHVSA-N

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此商品
81053381053N810535
Bovine Serum Albumin ≥98.5%, New Zealand origin

BSAVRO

Bovine Serum Albumin

Bovine Serum Albumin Fraction V pack of 100 g

810533

Bovine Serum Albumin Fraction V

Bovine Serum Albumin Fraction V pack of 10 g

81053N

Bovine Serum Albumin Fraction V

Bovine Serum Albumin Fraction V pack of 5 kg

810535

Bovine Serum Albumin Fraction V

assay

≥98.5%

assay

≥98% (purity)

assay

≥98% (purity)

assay

≥98% (purity)

technique(s)

ELISA: suitable, western blot: suitable, Southern blotting: suitable

technique(s)

blood typing: suitable ( )

technique(s)

blood typing: suitable ( )

technique(s)

blood typing: suitable ( )

origin

New Zealand origin

origin

USA origin

origin

USA origin

origin

USA origin

biological source

bovine

biological source

bovine serum

biological source

bovine serum

biological source

bovine serum

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

300

form

lyophilized

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

一般描述

柠檬苦素也称为柑橘柠檬苦素和吴茱萸内酯(evodin)，是存在于柑橘籽中的高浓度植物次生代谢产物。[1]属于柠檬苦素类衍生物。[2]
柠檬苦素可用于柑橘制品中柠檬苦素的定量测定。也可用于其他试验作为对照、标准品或竞品，或用于柠檬苦素的生理学、代谢和生物合成研究。

应用

柠檬苦素已用于：
  • 处理人外周血单个核细胞(PBMC)，检测其对人免疫缺陷型病毒(HIV)复制的影响[3]
  • 研究柠檬苦素作为抗骨质疏松剂，对MC3T3-E1细胞和去卵巢(OVX)大鼠模型中成骨细胞生成活性的影响[4]
  • 作为高效液相色谱(HPLC)体系的参考标准品[5]

生化/生理作用

柠檬苦素是一种三萜类糖苷配基，是柑橘类水果的苦味成分。它对几种癌细胞系具有抗增殖、凋亡的活性，并抑制由乙氧基甲烷诱导的大鼠结肠癌。它还可以通过抑制HIV-1蛋白酶的活性来抑制培养的单核细胞、巨噬细胞和单核细胞中的HIV-1复制。
柠檬苦素通过下调信号转导和转录活化因子3/microRNA-214(STAT3/miR-214)信号通路，在溃疡性结肠炎(UC)中发挥抗炎作用。[6]它可作为抗癌剂，在体外研究中参与下调无翅基因相关整合位点(Wnt)信号通路组分。[2]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000389395
    0000371475
    0000306210
    0000306210
    0000299743

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    Raju Lal Bhardwaj et al.
    Critical reviews in food science and nutrition, 51(6), 563-570 (2011-09-21)
    The post-harvest shelf life of maximum of fruits and vegetables is very limited due to their perishable nature. In India more then 20-25 percent of fruits and vegetables are spoiled before utilization. Despite being the world's second largest producer of
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    A simple, sensitive and accurate HPLC-DAD method was developed for simultaneous determination of wuchuyuamide-I, quercetin, limonin, evodiamine and rutaecarpine in Evodia rutaecarpa that has been widely used as one of the traditional Chinese medicines (TCMs). Chromatographic separations were performed on
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