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L9504

Sigma-Aldrich

D -荧光素

luminescent, ≥98% (HPLC), powder

别名:

( S )-2-（6-羟基-2-苯并噻唑基）-2-噻唑啉-4-羧酸, 4,5-二氢-2-（6-羟基-2-苯并噻唑基）-4-噻唑羧酸, 萤火虫荧光素

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About This Item

经验公式（希尔记法）:
C11H8N2O3S2
CAS号:
2591-17-5
分子量:
280.32
Beilstein:
30484
EC 号:
219-981-3
MDL编号:
MFCD00042929
UNSPSC代码:
12352204
PubChem化学物质编号:
24896524
NACRES:
NA.32

产品名称

D -荧光素, synthetic

生物来源

synthetic

质量水平

300

方案

≥98% (HPLC)

表单

powder

溶解性

DMSO: 10 mg/mL, clear, colorless to faintly yellow

荧光

λex 328 nm; λem 532 nm in H2O

储存温度

−20°C

SMILES字符串

OC(=O)[C@H]1CSC(=N1)c2nc3ccc(O)cc3s2

InChI

1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1

InChI key

BJGNCJDXODQBOB-SSDOTTSWSA-N

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一般描述

荧光素是一种大量存在于发光性生物体中的小分子。该分子对氧和光敏感。

应用

荧光素用于通过荧光素酶检测测定小鼠和拟南芥种子中的荧光素酶活性。它也被用于测量新生大鼠心室心肌细胞的生物发光。
Km 约为 2 μM 的萤火虫荧光素酶的底物。

生化/生理作用

细胞内的荧光素摄入受到三磷酸腺苷(ATP)结合盒(ABC)转运体抑制剂的调节，例如ATP结合盒转运子G2 (ABCG2)/乳腺癌耐受蛋白(BCRP)抑制剂烟曲霉毒素C等。这一基质被萤火虫萤光素酶氧化，发出能够穿过活组织的光量子。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
0000402759
0000398985
0000396026
0000343904
0000343905

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Imaging and Spectroscopic Analysis of Living Cells
Test (2012)
Matthias N van Oosterom et al.
EJNMMI research, 4, 56-56 (2014-11-12)
In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence-SPECT platform. Next
Caglar Cekic et al.
Cancer research, 74(24), 7239-7249 (2014-10-25)
Adenosine A(2A) receptor (A(2A)R) blockade enhances innate and adaptive immune responses. However, mouse genetic studies have shown that A(2A)R deletion does not inhibit the growth of all tumor types. In the current study, we showed that growth rates for ectopic
Erik Wennerberg et al.
Cancer immunology, immunotherapy : CII, 64(2), 225-235 (2014-10-27)
Adoptive infusion of natural killer (NK) cells is being increasingly explored as a therapy in patients with cancer, although clinical responses are thus far limited to patients with hematological malignancies. Inadequate homing of infused NK cells to the tumor site
Floris P R Verbeek et al.
Annals of surgical oncology, 21 Suppl 4, S528-S537 (2014-02-12)
Irradical tumor resections and iatrogenic ureteral injury remain a significant problem during lower abdominal surgery. The aim of the current study was to intraoperatively identify both colorectal tumors and ureters in subcutaneous and orthotopic animal models using cRGD-ZW800-1 and near-infrared
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