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一般描述
Lipodisq®试剂是来源于苯乙烯和马来酸的新型聚合物。Lipodisq®聚合物能够形成可在膜蛋白中结合的纳米脂质盘状颗粒。在pH 7.4下，Lipodisqs的直径通常为9-10 纳米。
应用
Lipodisq®试剂是来源于苯乙烯和马来酸的新型聚合物。 Lipodisq聚合物能够形成可在膜蛋白中结合的纳米脂质盘状颗粒。Lipodisq技术可以在不使用表面活性剂的情况下溶解常用的脂质，例如二肉豆蔻酰磷脂酰胆碱（DMPC）。通常，lipodisq聚合物有望用于减少膜蛋白增溶用洗涤剂的使用。在pH 7.4下，Lipodisqs的直径通常为9-10 纳米。
Lipodisq技术可以在不使用表面活性剂的情况下溶解常用的脂质，例如二肉豆蔻酰磷脂酰胆碱（DMPC）。
功能pH范围： 6.0 - 9.0
功能pH范围： 6.0 - 9.0
生化/生理作用
Lipodisq®聚合物有望用于减少膜蛋白增溶用清洁剂的使用。以足量碱（如KOH、NaOH）将本品溶解在水性溶液中，会导致每个酸酐基团水解成两个羧酸/羧酸酯基团。这种作用使SMA可以在水性介质中溶解。Lipodisq® 是一种潜在的膜模拟系统。
法律信息
Lipodisq is a registered trademark of Malvern Cosmeceutics Limited
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer Lipodisq particles for functional and biophysical studies
Orwick-Rydmark M, et al.
Nano Letters, 12(9), 4687-4692 (2012)
Juan F Bada Juarez et al.
Chemistry and physics of lipids, 222, 51-58 (2019-05-19)
Lipodisq™ nanoparticles have been used to extract surface lipids from the cuticle of two strains (wild type, N2 and the bacteria-resistant strain, agmo-1) of the C. elegans nematode without loss of viability. The extracted lipids were characterized by thin layer
Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies
Zhang R, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(1), 329-333 (2015)
Maria Lyngaas Torgersen et al.
Journal of biomedical nanotechnology, 16(4), 419-431 (2020-09-25)
Many promising pharmaceutically active compounds have low solubility in aqueous environments and their encapsulation into efficient drug delivery vehicles is crucial to increase their bioavailability. Lipodisq nanoparticles are approximately 10 nm in diameter and consist of a circular phospholipid bilayer
Indra D Sahu et al.
Biochemistry, 52(35), 5967-5984 (2013-08-22)
Electron paramagnetic resonance (EPR) spectroscopy is a very powerful biophysical tool that can provide valuable structural and dynamic information about a wide variety of biological systems. The intent of this review is to provide a general overview for biochemists and
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