推荐产品
生物来源
Escherichia coli (O26:B6)
质量水平
表单
lyophilized powder
比活
≥10,000 EU/mg
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: soluble
运输
ambient
储存温度
2-8°C
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相关类别
一般描述
该产品是来自大肠杆菌血清型 O26：B6的酚提取物。源菌株是ATCC 12795。来自血清型 026的LPS：B6是来自大肠杆菌的唯一 LPS，其在SDS-PAGE 上表现出短链长行为。该 LPS的短链长度接近突变粗糙株 LPS的短链长。该 LPS 血清型（1ug/ml），用于刺激中性粒细胞。
应用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖（LPS）位于膜的外层，在非包封的菌株中，暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的影响。
制备说明
产物可溶于水（5mg/ml）或细胞培养基（1mg/ml），产生浑浊的、淡黄色溶液。在经过涡旋和加温至 70-80oC 后，在水溶的盐水中得到更浓缩、但仍然浑浊的溶液（20mg/ml）。脂多糖是在各种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。有机溶剂不能提供更澄清的溶液。甲醇产生具有漂浮物的混浊悬浮液，而水产生均匀混浊的溶液。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Marie-Anne Mawhin et al.
Cardiovascular research, 114(12), 1656-1666 (2018-05-26)
Both leukotrienes and neutrophils have been linked to plaque destabilization. Despite being evoked, the role of leukotriene B4 (LTB4) in neutrophil recruitment to plaques and the concomitant effects of these two actors on plaque stability remain to be proven. Since
Yvonne Huber et al.
Cell death & disease, 8(6), e2893-e2893 (2017-06-24)
Physical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury
Una Avdic et al.
Frontiers in neurology, 10, 701-701 (2019-07-25)
Non-convulsive status epilepticus (NCSE) is a prolonged epileptic seizure with subtle symptoms that may delay clinical diagnosis. Emerging experimental evidence shows brain pathology and epilepsy development following NCSE. New diagnostic/prognostic tools are therefore needed for earlier and better stratification of
Khandaker Ahtesham Ahmed et al.
The Biochemical journal, 441(2), 719-730 (2011-10-05)
8-Nitro-cGMP (8-nitroguanosine 3',5'-cyclic monophosphate) is a nitrated derivative of cGMP, which can function as a unique electrophilic second messenger involved in regulation of an antioxidant adaptive response in cells. In the present study, we investigated chemical and biochemical regulatory mechanisms
Hayley T Nicholls et al.
Diabetes, 60(4), 1100-1110 (2011-03-08)
The fatty acid translocase and scavenger receptor CD36 is important in the recognition and uptake of lipids. Accordingly, we hypothesized that it plays a role in saturated fatty acid-induced macrophage lipid accumulation and proinflammatory activation. In vitro, the effect of
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