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生物来源
plant oil (safflower)
质量水平
方案
≥97% (GC)
表单
powder
技术
activity assay: suitable
颜色
white
mp
230 °C (446 °F)
溶解性
methanol: 50 mg/mL, clear, yellow
应用
general analytical
life science and biopharma
官能团
carboxylic acid
一般描述
亚油酸是一种ω-6多不饱和必需脂肪酸(PUFA)，它是花生四烯酸(AA)的前体，也是合成前列腺素和其它类二十烷酸的必要物质。作为一种必需脂肪酸，亚油酸必须通过膳食获取，因为人体不能生成它。亚油酸缺乏与伤口愈合不良、生长迟缓和皮炎等健康问题有关。花生四烯酸15脂氧合酶（15-LO）可以代谢植物和动物体内的亚油酸，从而形成9-和13-羟基十八碳二烯酸（HODE）。这种多功能分子的应用领域包括生物化学、代谢组学和脂质组学研究，它便于研究人员研究各种代谢途径，并提供了有关活生物体内脂质功能的信息。
应用
亚油酸钠盐已用于：
- β-胡萝卜素亚油酸含量测定
- 用作基础培养基成分，处理外周血单核细胞（PBMC）
- 杜氏改良 Eagle培养基（DMEM）/F-12 HEPES（4-（2-羟乙基）哌嗪-1-乙磺酸），孵育人滋养层来源的绒毛膜癌细胞（BeWo），并研究其对粘附连接（AJ）标记水平、细胞层通透性和细胞内脂质积聚的影响
生化/生理作用
作为酰基糖基神经酰胺组分，亚油酸在维持皮肤的透水屏障方面发挥着生理作用。亚油酸缺乏可能导致婴儿生长发育不良、鳞状皮炎和免疫反应受损。这一物质用于化妆品和个人护理产品。亚油酸主要用作皮肤、指甲和头发的润肤剂或保湿剂。
特点和优势
- 适用于多种研究应用的优质分子
- 常用于代谢组学和生物化学研究
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
E P Kilsdonk et al.
Journal of lipid research, 33(9), 1373-1382 (1992-09-01)
Human endothelial cells (EA.hy 926 line) were loaded with cationized low density lipoprotein (LDL) and subsequently incubated with fatty acid/bovine serum albumin complexes. The fatty acids were palmitic, oleic, linoleic, arachidonic, and eicosapentaenoic acids. The preincubations resulted in extensively modified
Hila Seti et al.
Archives of physiology and biochemistry, 115(3), 127-136 (2009-06-02)
The insulin-like growth factor (IGF) system plays a critical role in normal growth and development as well as in malignant states. Most of the biological activities of the IGFs are mediated by the IGF-IR, which is over-expressed in most tumours
T Sakamoto et al.
Applied and environmental microbiology, 64(7), 2361-2366 (1998-07-02)
Laboratory conditions have been identified that cause the rapid death of cultures of cyanobacteria producing urease. Once the death phase had initiated in the stationary growth phase, cells were rapidly bleached of all pigmentation. Null mutations in the ureC gene
Moran Cohen-Berkman et al.
eLife, 9 (2020-03-28)
How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs
Miriam E van Gent et al.
Antibiotics (Basel, Switzerland), 11(5) (2022-05-29)
Recently, using a deep learning approach, the novel antibiotic halicin was discovered. We compared the antibacterial activities of two novel bactericidal antimicrobial agents, i.e., the synthetic antibacterial and antibiofilm peptide (SAAP)-148 with this antibiotic halicin. Results revealed that SAAP-148 was
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