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一般描述
No detectable growth in tryptone soy broth at 30-35 °C for 14 days
生化/生理作用
β-Lactamases exhibit high carbapenemase activity. β-lactamases can destroy the β-lactam ring. True carbapenemases has the ability to hydrolyse several β-lactam ring containing carbapenems like meropenem, doripenem, imipenem and ertapenem.
组分
600-1500 IU beta-lactamase I per vial
60-150 IU beta-lactamase II per vial
60-150 IU beta-lactamase II per vial
单位定义
One unit will hydrolyze 1.0 μmole substrate per min (βI: benzylpenicillin; βII: cephalosporin C) in phosphate buffer, pH 7.0 at 25°C.
外形
Lyophilized powder containing sodium chloride, potassium phosphate, dipotassium phosphate and sorbitol.
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Identification and screening of carbapenemase-producing Enterobacteriaceae
Nordmann P, et al.
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(5), 432-438 (2012)
Lisa M Miller et al.
ACS applied materials & interfaces, 11(36), 32599-32604 (2019-08-27)
Antimicrobial resistance (AMR) has been identified as a major threat to public health worldwide. To ensure appropriate use of existing antibiotics, rapid and reliable tests of AMR are necessary. One of the most common and clinically important forms of bacterial
Mechanisms and Detection of Antimicrobial Resistance
Principles and Practice of Pediatric Infectious Diseases (Fourth Edition), 1467-1478 (2017)
Matthew D Simmons et al.
Antibiotics (Basel, Switzerland), 9(10) (2020-10-03)
The misuse of antibiotics in health care has led to increasing levels of drug resistant infections (DRI's) occurring in the general population. Most technologies developed for the detection of DRI's typically focus on phenotyping or genotyping bacterial resistance rather than
Satoshi Nakagawa et al.
The Japanese journal of antibiotics, 66(5), 251-264 (2014-02-18)
We investigated the antimicrobial activity of several drugs against 131 extended-spectrum beta-lactamase (ESBL) positive clinical isolates in Gifu and Aichi prefecture from 2007 to 2011. Meropenem (MEPM) and doripenem (DRPM) gave the lowest MIC50 at 0.0313 microg/mL. MEPM gave the
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