推荐产品
应用
人血浆来源低密度脂蛋白用于：
- 用作无胆固醇RPMI培养基中的添加剂
- 用作缓冲液组分，以执行测定脂质过氧化测定
- 刺激肝巨噬细胞
- 用作通过平衡透析法测定帕唑帕尼未结合组分(fu%)的血浆蛋白
生化/生理作用
LDL和HDL负责在血浆中运输饮食和内源胆固醇。LDL是胆固醇和胆固醇脂的主要载体，组成了血浆中总脂蛋白的一半以上。LD通过受体介导内吞作用，被肝脏和其他组织吸收。LDL受体的胞浆结构域帮助形成被小窝，膜上的受体富集区域。受体配体结合域识别LDL上的 apo-B100，导致包被网格蛋白的囊泡形成。ATP依赖质子泵减低囊泡内的pH，导致LDL从它的受体上脱离。当网格蛋白囊泡和溶菌酶融合丧失，会导致多肽和胆固醇脂酶水解。LDL受体会循环至细胞膜。胰岛素，三碘甲状腺原氨酸和地塞米松被证明参与调解LDL受体介导的摄入。
注意
冷冻脂蛋白溶液可能导致结构或组分变化。
物理属性
低密度脂蛋白比VLDL和IDL（26nm）（MW大约3.5百万）分子质量小，而且更稠密 (~1.04)。LDL蛋白质组分是载脂蛋白 B100。LDL含有20-22%蛋白质，10-15%甘油三酯，20-28%磷酸酯，37-48%胆固醇脂和8-10%胆固醇。
外形
含150mM NaCl和0.01%EDTA的溶液，pH7.4
其他说明
免责声明
仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Shu-Ping Hui et al.
Analytical and bioanalytical chemistry, 403(7), 1831-1840 (2012-03-01)
1-Palmitoyl-2-linoleoylphosphatidylcholine monohydroperoxide (PC 16:0/18:2-OOH) and 1-stearoyl-2-linoleoylphosphatidylcholine monohydroperoxide (PC 18:0/18:2-OOH) were measured by liquid chromatography/mass spectrometry (LC/MS) using nonendogenous 1-palmitoyl-2-heptadecenoylphosphatidylcholine monohydroperoxide as an internal standard. The calibration curves for synthetic PC 16:0/18:2-OOH and PC 18:0/18:2-OOH, which were obtained by direct injection
Isolation and analysis of human plasma lipoproteins accumulating postrandial in an intermediate density fraction (d 1.006--1.019 g-ml).
R Fellin et al.
Clinica chimica acta; international journal of clinical chemistry, 54(3), 325-333 (1974-08-20)
Matthew R Sobansky et al.
Analytical and bioanalytical chemistry, 403(2), 563-571 (2012-02-23)
Columns containing immobilized low-density lipoprotein (LDL) were prepared for the analysis of drug interactions with this agent by high-performance affinity chromatography (HPAC). R/S-Propranolol was used as a model drug for this study. The LDL columns gave reproducible binding to propranolol
Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high-fat diet
Miura K, et al.
Cancer Science, 110(2), 771-771 (2019)
Leanne Satchell et al.
Biochemistry, 51(18), 3767-3775 (2012-04-13)
Low-density lipoprotein (LDL) has recently been shown to be oxidized by iron within the lysosomes of macrophages, and this is a novel potential mechanism for LDL oxidation in atherosclerosis. Our aim was to characterize the chemical and physical changes induced
商品
由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
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