推荐产品
生物来源
Salmonella enterica (Serotype typhimurium)
质量水平
形式
lyophilized powder
纯化方式
trichloroacetic acid extraction
杂质
1-10% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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一般描述
本品为从鼠伤寒沙门氏菌中提取的 TCA。来源菌株为 ATCC 7823。该 LPS 血清型已被用于诱导大鼠和豚鼠的 NOS。
应用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，Toll样受体 4是Toll样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖 (LPS) 位于膜的外层，并且在非包封的菌株中，其暴露于细胞表面。它们有助于外膜的完整性，并可保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
该产品可溶于水（5mg / ml）或细胞培养基（1mg / ml），产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后，在盐水中可获得更高浓度的溶液（20mg/ml），但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液，而水会产生均匀的混浊溶液。
相关产品
产品编号
说明
价格
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Matthew B Toomey et al.
The Journal of experimental biology, 213(Pt 10), 1709-1716 (2010-05-04)
The costs of developing, maintaining, and activating the immune system have been cited as an important force shaping life-history evolution in animals. Immunological defenses require energy, nutrients and time that might otherwise be devoted to other life-history traits like sexual
Melissa S Monson et al.
Scientific reports, 9(1), 13649-13649 (2019-09-22)
Exposure to high temperatures is known to impair immune functions and disease resistance of poultry. Characterizing changes in the transcriptome can help identify mechanisms by which immune tissues, such as the thymus, respond to heat stress. In this study, 22-day-old
Maria Fort et al.
Veterinary immunology and immunopathology, 129(1-2), 101-107 (2009-01-27)
The interaction between porcine circovirus type 2 (PCV2) and the pig immune system has been suggested to be a determinant event for the pathogenesis of postweaning multisystemic wasting syndrome (PMWS). To gain insight into the host immune mechanisms developed upon
Melissa S Monson et al.
BMC genomics, 19(1), 643-643 (2018-09-01)
Exposure to heat stress suppresses poultry immune responses, which can increase susceptibility to infectious diseases and, thereby, intensify the negative effects of heat on poultry welfare and performance. Identifying genes and pathways that are affected by high temperatures, especially heat-induced
Haibo Huang et al.
BMC genomics, 17, 322-322 (2016-05-05)
Thymus is the crucial site for T cell development and once believed to be immune privileged. Recently, thymus has gained special attention as it is commonly targeted by infectious agents which may cause pathogenic tolerance and subsequent immunosuppression. We analyzed
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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