所有图片(4)
About This Item
经验公式（希尔记法）:
C21H41O7P · xNa+
CAS号:
分子量:
436.52 (free acid basis)
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98%
形式
solid
颜色
white
脂质类型
phosphoglycerides
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
InChI
1S/C21H41O7P.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);;/b10-9+;;
InChI key
CHJOEWDRTPWOCY-TTWKNDKESA-N
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一般描述
溶血磷脂酸（LPA）是一种基本的膜生物合成代谢物。LPA和G蛋白偶联受体（GPCRs）互作，被称为LPA受体，调节信号反应。油酰-L-α-溶血磷脂酸激活LPA4受体。在角质形成细胞中，油酰-L-α-溶血磷脂酸在某种程度上促进生长。
应用
油酰-L-α-溶血磷脂酸钠盐用于：
- Ras同源基因家族成员A（RhoA）活化和人乳腺癌上皮细胞系claudin-1表达。
- RH7777细胞环腺苷酸(cAMP)积累分析和钙移动分析
- 体外荧光素酶分析和活细胞成像
生化/生理作用
LPA1 和 LPA2 受体的内源性激动剂。LPA 不能诱导血管生成，但会影响内皮细胞生理机能（与 1-磷酸鞘氨醇类似）。诱导癌细胞和非癌细胞的细胞迁移。
注意
吸湿、光敏
制备说明
通过磷脂酶 A 作用于二油酰-L-α-磷脂酸制得。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Tracee Scalise Panetti
Biochimica et biophysica acta, 1582(1-3), 190-196 (2002-06-19)
This review discusses multiple effects of sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) on endothelial cells and proposes that S1P and LPA are important regulators of the vascular system. Two physiologic sources of S1P and LPA are platelets and lipoproteins.
A Gohla et al.
The Journal of biological chemistry, 273(8), 4653-4659 (1998-03-21)
Lysophosphatidic acid (LPA) utilizes a G-protein-coupled receptor to activate the small GTP-binding protein Rho and to induce rapid remodeling of the actin cytoskeleton. We studied the signal transduction from LPA receptors to Rho activation. Analysis of the G-protein-coupling pattern of
T Nishizaki et al.
Brain research. Molecular brain research, 50(1-2), 121-126 (1997-12-24)
The effect of lysophosphatidic acid (lysoPA) on acetylcholine (ACh)-evoked currents was examined using normal and mutant Torpedo nicotinic ACh receptors expressed in Xenopus oocytes. LysoPA enhanced ACh-evoked currents in a washing time- and dose-dependent manner at concentrations of 0.1-3 microM
Identification of compounds acting as negative allosteric modulators of the LPA 1 receptor
Ellery J, et al.
European Journal of Pharmacology (2018)
TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4
Kuipers AJ, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(7), 2409-2419 (2018)
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