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方案
≥95% (HPLC)
质量水平
表单
film
溶解性
DMSO: soluble 25 mg/mL
储存温度
−20°C
SMILES字符串
[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI
1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI key
FWPWHHUJACGNMZ-NBBQQVJHSA-N
应用
Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。
Clasto-乳胞素β-内酯已用作蛋白降解抑制剂以检测其对小鼠记忆改善的作用。它还用作人卵巢上皮(HOSE)细胞和树突状细胞(DC)的蛋白酶体抑制剂。
生化/生理作用
Clasto-乳胞素β-内酯(cLβL)由乳胞素(Lactacystin)合成。它具有细胞可透过性。cLβL可作用于蛋白酶体β -亚基X的N端苏氨酸。还可通过作用于β -型亚基的N-苏氨酸残基，抑制嗜盐古菌Haloferax volcanii的20S蛋白酶体活性。
细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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