推荐产品
检测方案
≥95% (HPLC)
质量水平
形式
film
溶解性
DMSO: soluble 25 mg/mL
储存温度
−20°C
SMILES字符串
[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI
1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI key
FWPWHHUJACGNMZ-NBBQQVJHSA-N
应用
Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。
Clasto-乳胞素β-内酯已用作蛋白降解抑制剂以检测其对小鼠记忆改善的作用。它还用作人卵巢上皮(HOSE)细胞和树突状细胞(DC)的蛋白酶体抑制剂。
生化/生理作用
Clasto-乳胞素β-内酯(cLβL)由乳胞素(Lactacystin)合成。它具有细胞可透过性。cLβL可作用于蛋白酶体β -亚基X的N端苏氨酸。还可通过作用于β -型亚基的N-苏氨酸残基,抑制嗜盐古菌Haloferax volcanii的20S蛋白酶体活性。
细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(44), 11333-11341 (2006-11-03)
The ubiquitin proteasome system, generally known for its function in protein degradation, also appears to play an important role in regulating membrane trafficking. A role for the proteasome in regulating presynaptic release and vesicle trafficking has been proposed for invertebrates
Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2
The Journal of Neuroscience, 34(13), 4494-4508 (2014)
Traffic (Copenhagen, Denmark), 8(9), 1205-1214 (2007-07-17)
Intracellular trafficking of viral movement proteins (MPs) in plants has mainly been studied using Tobacco mosaic virus MP30 (TMV MP30) as a model system. Because of the limitations of TMV MP30 expression in Arabidopsis thaliana, these studies have mostly been
Science (New York, N.Y.), 319(5867), 1253-1256 (2008-02-09)
Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved
Molecular and cellular endocrinology, 265-266, 51-58 (2007-01-16)
Steroidogenic acute regulatory protein (StAR) is a mitochondrial protein essential for massive synthesis of steroid hormones in the adrenal and the gonads. Our studies suggest that once synthesized on free polyribosomes, StAR preprotein either associates with the outer mitochondrial membrane
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