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Merck
CN

L6785

乳酸胱氨酸

≥90% (HPLC), powder, proteosome inhibitor

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关于此项目

经验公式（希尔记法）:
C15H24N2O7S
化学文摘社编号:
133343-34-7
分子量:
376.43
MDL编号:
MFCD01076525
UNSPSC代码:
12352200
PubChem化学物质编号:
24896445
NACRES:
NA.77

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产品名称

乳酸胱氨酸, ≥90% (HPLC)

质量水平

200

方案

≥90% (HPLC)

表单

powder

效能

4 nM Ki (proteasome inhibitor)

溶解性

water: 10 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O

InChI

1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1

InChI key

DAQAKHDKYAWHCG-RWTHQLGUSA-N

相关类别

一般描述

乳酸菌素作为一种抗生素，是链霉菌的代谢物。

应用

使用乳胞素：
  • 作为蛋白酶体抑制剂，抑制蛋白质降解
  • 抑制细胞蛋白酶体活性，为活细胞成像
  • 阻断人单核细胞来源的树突状细胞(MoDC)中蛋白酶体蛋白水解长达24小时
  • 对动物进行单侧注射，诱导黑纹状体病变

生化/生理作用

乳酸菌素在小鼠神经母细胞瘤细胞系中具有抑制细胞周期发育、刺激分化等作用。它可以作为Clasto-乳胞素β-内酯的前体。细胞可透过性和不可逆蛋白酶体抑制剂(Ki = 4nM)。抑制NF-kB的活化(IC50 = 10mM)。在neuro2A小鼠神经母细胞瘤细胞中诱导神经突生长。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCT8161
MKCL8926
MKCF1940
MKCC0039
MKBV3037V

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Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin A CENTRAL ROLE FOR clasto-LACTACYSTIN beta-LACTONE
Dick L R, et al.
The Journal of Biological Chemistry, 271(13), 7273-7276 (1996)
Dallas S Shi et al.
The Journal of clinical investigation, 124(9), 3757-3766 (2014-07-26)
The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of
Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease
Vernon A C, et al.
PLoS ONE, 6(2), e17269-e17269 (2011)
Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells
Landsverk O J B, et al.
Journal of Leukocyte Biology, 91(5), 729-737 (2012)
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through Galphao/i-triggered proteasomal degradation of Rap1GAPII
Jordan J D, et al.
The Journal of Biological Chemistry, 280(12), 11413-11421 (2005)
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Product Information Sheet - L6785

Product Information Sheet

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