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生物来源
Salmonella enterica (Serotype typhimurium)
质量水平
表单
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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相关类别
一般描述
本品为从鼠伤寒沙门菌中提取的苯酚。来源菌株为 ATCC 7823。该 LPS 已被用于诱导大鼠和豚鼠的 NOS。
应用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，Toll样受体 4是Toll样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖 (LPS) 定位于膜的外层，在无荚膜的菌株中暴露于细胞表面。它们有助于外膜的完整性，并保护细胞免受胆盐和亲脂性抗生素的操作。
制备说明
本品可溶于水 (5 mg/mL) 或细胞培养基 (1 mg/mL)，得到淡黄色浑浊溶液。涡旋并加热至 70-80 oC 后，在盐水中获得了更浓缩但仍浑浊的溶液 (20 mg/mL)。脂多糖是在每种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到浑浊溶液。有机溶剂不能提供更清晰的溶液。甲醇产生浑浊的带有悬浮物的混悬液，而水产生均匀的浑浊溶液。
相关产品
产品编号
说明
价格
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sanjoy Kumar Bhunia et al.
Carbohydrate research, 345(17), 2542-2549 (2010-10-12)
A water-soluble polysaccharide, isolated from the hot water extract of the fruiting bodies of an edible mushroom, Lentinus squarrosulus (Mont.) Singer was found to contain d-galactose, l-fucose, and d-glucose in a molar ratio of nearly 1:1:5. Structural investigation of the
Mary K Collins et al.
The Journal of clinical investigation, 119(7), 2062-2073 (2009-06-24)
Embryo implantation induces formation of the decidua, a stromal cell-derived structure that encases the fetus and placenta. Using the mouse as a model organism, we have found that this tissue reaction prevents DCs stationed at the maternal/fetal interface from migrating
Alejandro Carrillo-Jimenez et al.
Frontiers in cellular neuroscience, 12, 313-313 (2018-10-10)
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer's disease (AD). The use of primary microglial cell cultures has proved to be a valuable tool to study microglial biology under various
C Marcq et al.
Poultry science, 90(1), 59-67 (2010-12-24)
In this study, Salmonella enterica serovar Typhimurium challenge models were tested to identify the best conditions under which to perform the experimental infection of 3-wk-old broilers. Such a model would be useful to study the efficiency of therapeutic treatments that
Gul N Shah et al.
The Journal of pharmacology and experimental therapeutics, 344(3), 637-645 (2012-12-20)
Diabetes-associated complications in the microvasculature of the brain are caused by oxidative stress, generated by overproduction of reactive oxygen species from hyperglycemia-induced accelerated oxidative metabolism of glucose. Pericytes, essential for the viability of the microvasculature, are especially susceptible to oxidative
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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