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生物来源
bacterial (Salmonella typhosa)
质量水平
形式
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to yellow cast
溶解性
water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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一般描述
本产品是从伤寒沙门氏菌中提取的苯酚。来源菌株为 ATCC 10749。
应用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS 及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，TLR4 是 Toll 样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
产物可溶于水（5mg/ml）或细胞培养基（1mg/ml），产生浑浊的淡黄色溶液。在经过涡旋，并升温至 70-80oC 后，含水盐水变得更浓缩，但仍然浑浊（20mg/ml）。脂多糖分子在每种溶剂中均形成胶束。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。使用有机溶剂，溶液也是浑浊的。甲醇产生具有漂浮物的浑浊悬浮液，而水则产生均匀浑浊的溶液。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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B D Forrest
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Intestinal fluid, saliva, circulating peripheral blood lymphocytes (PBL), and serum samples obtained from 81 human adult subjects who had been orally vaccinated with either Salmonella typhi Ty21a or one of its recombinant derivatives were examined to determine the value of
Sebastian Steven et al.
British journal of pharmacology, 174(12), 1620-1632 (2016-07-21)
Excessive inflammation in sepsis causes microvascular thrombosis and thrombocytopenia associated with organ dysfunction and high mortality. The present studies aimed to investigate whether inhibition of dipeptidyl peptidase-4 (DPP-4) and supplementation with glucagon-like peptide-1 (GLP-1) receptor agonists improved endotoxaemia-associated microvascular thrombosis
Hanxiao Tu et al.
Journal of cellular and molecular medicine, 24(2), 1256-1267 (2019-12-07)
Autoimmune hepatitis (AIH) is a chronic liver disease due to autoimmune system attacks hepatocytes and causes inflammation and fibrosis. Intracellular signalling and miRNA may play an important role in regulation of liver injury. This study aimed to investigate the potential
Yongqing Li et al.
Surgery, 156(2), 229-234 (2014-06-25)
We have recently demonstrated that in a rodent model of lipopolysaccharide (LPS)-induced shock, an increase in circulating citrullinated histone H3 (Cit H3) is associated with lethality of sepsis, and treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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