L6010
α-乳清蛋白 来源于牛奶
Type III, calcium depleted, ≥85% (PAGE), lyophilized powder
别名:
Bos d 4, Lactose synthase B protein, alpha-lactalbumin
产品名称
α-乳清蛋白 来源于牛奶, Type III, calcium depleted, ≥85% (PAGE), lyophilized powder
biological source
bovine milk
type
Type III
assay
≥85% (PAGE)
form
lyophilized powder
quality
calcium depleted
mol wt
14,178 Da by calculation
concentration
≥85 % protein
technique(s)
indirect ELISA: suitable
impurities
cation traces, tested
solubility
H2O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
cation traces
Ca: ≤0.3 mol/mol
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
cow ... LALBA(281894)
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Analysis Note
可能含微量 (NH4)2SO4 和磷酸钠。
Application
α-牛乳乳清蛋白已用于：
- 间接酶联免疫吸附测定（ELISA）和竞争性ELISA方法
- Hsp90和HSJ1b结合分析
- 抑制溶菌酶CAP-RAST测定体系
Biochem/physiol Actions
α-乳清蛋白是人乳中的主要蛋白。它由含有8个半胱氨酸（可形成二硫键）的单个多肽链组成。α-乳清蛋白可结合包括钙在内的几种金属离子，这被认为有助于从还原的变性形式α-乳清蛋白中再生天然形式的α-乳清蛋白。α-乳清蛋白还具有独特的锌结合位点，其被认为在乳糖合酶复合物的结合中起作用。其成熟蛋白由123个氨基酸残基（14kD）组成，具有1.7埃分辨率的三维结构，包含四个α-螺旋和三链反平行β-折叠。
其可通过改变半乳糖基转移酶的底物特异性以增加乳糖形成的速率；半乳糖基转移酶和 α-乳白蛋白的复合物称为乳糖合酶。
其可通过改变半乳糖基转移酶的底物特异性以增加乳糖形成的速率；半乳糖基转移酶和α-乳白蛋白的复合物称为乳糖合酶。Asp87 或 Asp88 对 Ala 的定点诱变完全消除了强钙结合亲和力，并将乳糖合酶的刺激降低到最大速率的 <3.5%。
General description
可能含有微量的(NH4)2SO4和磷酸钠L6010
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
Prevalence of lysozyme sensitization in an egg-allergic population
Fremont S, et al.
Allergy, 52(2), 224-228 (1997)
Melanie Jannaway et al.
Frontiers in physiology, 12, 687563-687563 (2021-10-09)
Lymphatic vascular permeability prevents lymph leakage that is associated with lymphedema, lymphatic malformations, obesity, and inflammation. However, the molecular control of lymphatic permeability remains poorly understood. Recent studies have suggested that adherens junctions and vesicle transport may be involved in
Effect of conjugation of cow milk whey protein with polyethylene glycol on changes in their immunoreactive and allergic properties
Wroblewska B and Jedrychowski L
Food and agricultural immunology, 14(2), 155-162 (2002)
T Schnaider et al.
Life sciences, 67(12), 1455-1465 (2000-09-13)
The 90 kDa heat shock protein (Hsp90) is a major cytoplasmic molecular chaperone associating with numerous other proteins. Both genetic and in vitro refolding experiments using reticulocyte lysate have suggested a functional interaction of Hsp90 with yeast human homologues of
Ozgür Tarhan et al.
The Journal of dairy research, 81(1), 98-106 (2013-12-20)
Alpha-lactalbumin (α-la) is one of the major proteins in whey. When partially hydrolysed with Bacillus licheniformis protease, it produces nanotubular structures in the presence of calcium ions by a self-assembly process. This study presents investigation of α-la protein structure during
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