L5420
Lumefantrine
别名:
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol, Benflumetol, CPG-56695
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C30H32Cl3NO
化学文摘社编号:
分子量:
528.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
DYLGFOYVTXJFJP-MYYYXRDXSA-N
SMILES string
CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12
InChI
1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: 2 mg/mL, clear (warmed)
originator
Novartis
storage temp.
room temp
Quality Level
正在寻找类似产品? 访问 产品对比指南
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Lumefantrine, also known as benflumetol is an aryl-amino alcohol. It is a member of the group of arylamine alcohols like quinine, mefloquine and halofantrine.
Application
Lumefantrine has been used:
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies
Biochem/physiol Actions
Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Karin Källander et al.
Trials, 16, 157-157 (2015-04-16)
If trained, equipped and utilised, community health workers (CHWs) delivering integrated community case management for sick children can potentially reduce child deaths by 60%. However, it is essential to maintain CHW motivation and performance. The inSCALE project aims to evaluate
Anti-infective agents
Drugs During Pregnancy and Lactation, 115-176 (2015)
Antimalarial drugs
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 495-509 (2014)
Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether-lumefantrine treatment in Mali
Dama S, et al.
Malaria Journal, 16(1), 59-59 (2017)
Thomas T Thomsen et al.
The American journal of tropical medicine and hygiene, 85(6), 979-983 (2011-12-07)
Tanzania implemented artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in November of 2006 because of resistance to sulfadoxine-pyrimethamine. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance, which initially may be detected at
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持