L5420
Lumefantrine
别名:
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol, Benflumetol, CPG-56695
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关于此项目
经验公式（希尔记法）:
C30H32Cl3NO
化学文摘社编号:
分子量:
528.94
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
质量水平
表单
powder
颜色
yellow
溶解性
DMSO: 2 mg/mL, clear (warmed)
创始人
Novartis
储存温度
room temp
SMILES字符串
CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12
InChI
1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
InChI key
DYLGFOYVTXJFJP-MYYYXRDXSA-N
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相关类别
一般描述
Lumefantrine, also known as benflumetol is an aryl-amino alcohol. It is a member of the group of arylamine alcohols like quinine, mefloquine and halofantrine.
应用
Lumefantrine has been used:
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies
生化/生理作用
Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
特点和优势
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Karin Källander et al.
Trials, 16, 157-157 (2015-04-16)
If trained, equipped and utilised, community health workers (CHWs) delivering integrated community case management for sick children can potentially reduce child deaths by 60%. However, it is essential to maintain CHW motivation and performance. The inSCALE project aims to evaluate
Lumefantrine and o-choline-Parasite metabolism specific drug molecules inhibited in vitro growth of Theileria equi and Babesia caballi in MASP culture system
Maji C, et al.
Ticks and Tick-Borne Diseases, 10(3), 568-574 (2019)
Use of a model procedure for transfer of Minilab qualitative screening TLC methods for lumefantrine and artemether in a combined tablet formulation to individual and simultaneous quantitative HPTLC-densitometry methods
Nguyen M and Sherma J
Malaria Journal (2013)
Thomas T Thomsen et al.
The American journal of tropical medicine and hygiene, 85(6), 979-983 (2011-12-07)
Tanzania implemented artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in November of 2006 because of resistance to sulfadoxine-pyrimethamine. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance, which initially may be detected at
Quique Bassat et al.
Malaria journal, 10, 369-369 (2011-12-20)
Artemisinin-based combination therapy, including artemether-lumefantrine (AL), is currently recommended for the treatment of uncomplicated Plasmodium falciparum malaria. The objectives of the current analysis were to compare the efficacy and safety of AL across different body weight ranges in African children
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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