L5288
Latrunculin B
from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor
别名:
LAT-B
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关于此项目
经验公式（希尔记法）:
C20H29NSO5
化学文摘社编号:
分子量:
395.51
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
拉春库林 B 来源于Latruncula magnifica, ≥80% (HPLC), solid
Quality Level
assay
≥80% (HPLC)
form
solid
mol wt
395.5
solubility
ethanol: soluble
storage temp.
−20°C
SMILES string
C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1
InChI
1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
InChI key
NSHPHXHGRHSMIK-JRIKCGFMSA-N
General description
拉春库林 B是一种大环毒素，由红海海绵（Latruncula magnifica ）产生。
Application
来自红海海绵（Latruncula magnifica ）的拉春库林 B在各种实验中用于肌动蛋白解聚。它还被用作骨髓来源树突状细胞 （BMDC）完全培养基中的一种成分，用于研究树突状细胞中吞噬体小管的形成。
Biochem/physiol Actions
拉春库林B 在体外抑制肌动蛋白聚合。拉春库林B破坏了微丝介导的过程。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--病毒，疫苗等
此项目有
Development of the theta comparative cell scoring method to quantify diverse phenotypic responses between distinct cell types
Warchal SJ, et al.
Assay and Drug Development Technologies, 14(7), 395-406 (2016)
Microtubule-dependent targeting of the exocyst complex is necessary for xylem development in Arabidopsis
Vukavsinovic N, et al.
The New phytologist, 213(3), 1052-1067 (2017)
Steven L Jones et al.
The Journal of cell biology, 205(1), 67-81 (2014-04-09)
The axon initial segment (AIS) of differentiated neurons regulates action potential initiation and axon-dendritic polarity. The latter function depends on actin dynamics, but actin structure and functions at the AIS remain unclear. Using platinum replica electron microscopy (PREM), we have
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L5288-1MG | 04061833958025 |