一般描述
来自Triticum vulgaris的小麦胚芽凝集素（WGA）以同型二聚体形式存在，并且具有多个N-乙酰葡糖胺（GlcNAc）结合位点。它对蛋白质变性剂具有抗性，可用于检测 O-GlcNAc蛋白。 WGA与N-乙醇酰神经氨酸（Neu5Ac）结合可调节促炎免疫应答。
应用
来自Triticum vulgaris （小麦）的凝集素已被用于：
- 丝虫寄生虫的子宫内阶段的样品的凝集素结合测定中
- 小鼠心肌细胞的组织学研究中
- 与Dynabeads一起形成珠子-生物素-WGA复合物® M-280链霉抗生物素蛋白磁珠，用于对来自水样中的弓形虫卵母细胞中的凝集素进行磁性分离
生化/生理作用
WGA 不具有血型特异性，但具有与 N-乙酰基-β-D-葡糖胺残基和 N-乙酰基-β-D-葡糖胺低聚物的亲和性。WGA 不含蛋白结合糖。
包装
包装尺寸基于蛋白质含量。
外形
含有柠檬酸钠
制备说明
由亲和纯化凝集素制备偶联物。
法律信息
Dynabeads is a registered trademark of Invitrogen Dynal AS Corp
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
A flow cytometry based method for studying embryogenesis and immune reactivity to embryogenic stages in filarial parasites
Sahu BR, et al.
Filaria Journal, 4(1), 11-11 (2005)
The dietary intake of wheat and other cereal grains and their role in inflammation
De PK and Pruimboom L
Nutrients, 5(3), 771-787 (2013)
Evaluation of bi-ventricular coronary flow patterns using high-frequency ultrasound in mice with transverse aortic constriction
Wu J, et al.
Ultrasound in Medicine & Biology, 39(11), 2053-2065 (2013)
WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins
Kubota Y, et al.
Testing, 12(7), e0180714-e0180714 (2017)
Jemere Bekele Harito et al.
Water research, 127, 68-76 (2017-10-17)
Proof-of-principle of lectin-magnetic separation (LMS) for isolating Toxoplasma oocysts (pre-treated with 0.5% acidified pepsin (AP)) from water for subsequent detection by microscopy or molecular methods has been shown. However, application of this technique in the routine water-analysis laboratory requires that
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