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一般描述
亮氨酸氨肽酶属于金属蛋白酶家族。
应用
猪肾来源微粒体亮氨酸氨肽酶用于从啮齿动物脑-C5 中分离脑啡肽酶(NEP),用于肽消化。
生化/生理作用
亮氨酸氨肽酶底物特异性广。能水解肽直至产生脯氨酸残基,不会对脯氨酸继续降解。
单位定义
一个单位在37°C 下 pH 7.2 时每分钟将水解 1.0μ摩尔 L-亮氨酸-对硝基苯胺为 L -亮氨酸和对硝基苯胺(25°C 下可获得活性约为37°C 下的 40%)。以 L-亮氨酸对硝基苯胺为底物得到的活性是以 L-亮氨酸酰胺为底物得到的活性的 2-5 倍。
外形
3.5M (NH4)2SO4 溶液中的悬浮液,pH 7.7,含 10mM MgCl2
警示用语:
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Debittering of a Tryptic Digest of Bovine p-casein Using Porcine Kidney General Aminopeptidase and X-Prolydipeptidyl Aminopeptidase from Lactococcus lactis subsp. cremoris AM2
Journal of Food Science, 65(7), 1145-1150 (2000)
Organic & biomolecular chemistry, 15(12), 2575-2584 (2017-03-08)
We report a reaction-based strategy for the fluorogenic detection of protease activity. Based on the "covalent-assembly" probe design principle recently put forward by the Yang group for detection of Sarin related threats (J. Am. Chem. Soc., 2014, 136, 6594-6597), we
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity
Journal of medicinal chemistry, 46(13), 2641-2655 (2003)
Hypertension (Dallas, Tex. : 1979), 13(6 Pt 2), 910-915 (1989-06-01)
Leucine aminopeptidase M significantly reduced blood pressure for up to 40 minutes when infused intracerebroventricularly into anesthetized spontaneously hypertensive rats (SHR) from a mean +/- SEM of 190 +/- 4 to 94 +/- 7 mm Hg and also in normotensive
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain
The Journal of Biological Chemistry, 128(6), 897-902 (2000)
商品
以硫酸铵悬浮液形式提供的酶的使用指南
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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