L4543
抗-L1CAM 抗体，小鼠单克隆
clone UJ127.11, purified from hybridoma cell culture
别名:
抗-CAML1, 抗-L1 细胞粘附分子, 抗-MIC5, 抗-神经细胞粘附分子 L1
产品名称
抗-L1CAM 抗体，小鼠单克隆, clone UJ127.11, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
UJ127.11, monoclonal
form
buffered aqueous solution
mol wt
antigen 220-240 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.25-0.5 μg/mL using cell extracts of G361 cells (human melanoma)
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... L1CAM(3897)
Application
抗-L1CAM 抗体已用于免疫组化。
抗-L1CAM 抗体，小鼠单克隆可用于：
- 免疫组化
- 免疫沉淀
- 免疫印迹
- 免疫细胞化学
- 流式细胞仪
Biochem/physiol Actions
L1CAM基因（L1细胞粘附分子）编码一种糖蛋白，在发育和轴突捆绑过程中在轴突生长中发挥作用。它与雪旺细胞和轴突相互作用，介导神经元细胞迁移和神经元细胞存活。该蛋白的过度表达与肿瘤进展相关。研究表明，它介导卵巢癌和胰腺癌细胞的治疗耐药性。
L1细胞粘附分子(L1CAM) 对于人类中枢神经系统 (CNS) 的发育至关重要。该蛋白质负责其中的多种活动：神经突生长、粘附、束状和髓鞘形成。这些活动是通过L1CAM与CAM蛋白家族的各个成员、细胞外基质分子和信号受体的相互作用，通过涉及L1CAM细胞外结构域的相互作用介导的。L1CAM 基因突变可能与多种脑部疾病有关，例如 1 型 X 连锁痉挛性截瘫 (SPG1)、MASA 综合征和 ACC（胼胝体发育不全）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
L1CAM（L1 细胞粘附分子）基因编码免疫球蛋白超基因家族的成员。编码的蛋白质包含一个细胞质胞内结构域、一个单次跨膜区域和一个含有6个免疫球蛋白（Ig）和5个纤连蛋白（Fn）III样基序的胞外结构域。该基因定位于人类染色体Xq28。它包含29个外显子，编码包含19个氨基酸信号肽的1257个氨基酸的蛋白质和包含1238个氨基酸的功能性L1蛋白质。它主要表达于神经系统。
抗-L1CAM 抗体，小鼠单克隆抗体（小鼠 IgG1 同种型）衍生自杂交瘤 UJ127.11，该杂交瘤是由小鼠骨髓瘤细胞（P3-X63-Ag8-653 细胞）与脾脏细胞融合后产生的。L1 细胞粘附分子（L1CAM）蛋白属于细胞粘附分子（CAM）家族。
Immunogen
来自人胎脑的 L1CAM。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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