生物来源
bacterial (Klebsiella pneumoniae)
质量水平
形式
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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一般描述
该产品是从肺炎克雷伯菌通过苯酚提取而来。源菌株是 ATCC 15380。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且在非包封菌株中暴露在细胞表面上。它们有助于保持外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
本产品可溶于水（5mg/ml）或细胞培养基（1mg/ml），形成浑浊的淡黄色溶液。经过涡旋并升温至 70-80 oC 后，在盐水中可获得浓度更高、但仍然混浊的溶液（20mg/ml）。脂多糖分子在每种溶剂中都会形成胶束。在水和磷酸盐缓冲液中形成浑浊的溶液。在有机溶剂中也不会更清澈。在甲醛中形成具有漂浮物的浑浊悬浮液，而在水中则产生均匀浑浊的溶液。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Max C Jacobs et al.
PloS one, 15(11), e0241748-e0241748 (2020-11-05)
An increasing body of evidence is indicating that the gut microbiota modulates pulmonary inflammatory responses. This so-called gut-lung axis might be of importance in a whole spectrum of inflammatory pulmonary diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary
Sofia Monteiro et al.
Gut, 70(2), 379-387 (2020-04-04)
Systemic inflammation predisposes acutely decompensated (AD) cirrhosis to the development of acute-on-chronic liver failure (ACLF). Supportive treatment can improve AD patients, becoming recompensated. Little is known about the outcome of patients recompensated after AD. We hypothesise that different inflammasome activation
C Arnold Spek et al.
Cells, 10(9) (2021-09-29)
CCAAT/enhancer-binding protein delta (C/EBPδ) is a member of the C/EBP family of transcription factors. According to the current paradigm, C/EBPδ potentiates cytokine production and modulates macrophage function thereby enhancing the inflammatory response. Remarkably, however, C/EBPδ deficiency does not consistently lead
Nora S Wolff et al.
Intensive care medicine experimental, 8(1), 47-47 (2020-08-26)
The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendors can influence murine models of pulmonary lipopolysaccharide (LPS) inflammation
Teresa García-Lezana et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(3), 927-937 (2016-05-08)
Hepatic encephalopathy has traditionally been considered a reversible disorder. However, recent studies suggested that repeated episodes of hepatic encephalopathy cause persistent impairment leading to neuronal loss. The aims of our study were the development of a new animal model that
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
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