推荐产品
生物来源
Escherichia coli (O26:B6)
质量水平
表单
lyophilized powder
纯化方式
trichloroacetic acid extraction
杂质
1-10% Protein (Lowry)
颜色
white to yellow
溶解性
water: soluble
运输
ambient
储存温度
2-8°C
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一般描述
该产品是从大肠杆菌O26：B6血清型中提取的三氯乙酸。来源菌株为ATCC12795。来自血清型026：B6的LPS是来自大肠杆菌的唯一在SDS-PAGE上表现出短链长行为的LPS。该LPS的短链长度更接近于突变型粗菌株LPS的短链长度。
应用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中，其暴露于细胞表面。它们有助于外膜的完整性，并可保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
该产品可溶于水（5mg / ml）或细胞培养基（1mg / ml），产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后，在盐水中可获得更高浓度的溶液（20mg/ml），但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液，而水会产生均匀的混浊溶液。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Rupali Sharma et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 71, 94-104 (2018-08-31)
Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and
Guohui Cai et al.
Scientific reports, 6, 21097-21097 (2016-02-13)
Early life diet can critically program hypothalamic-pituitary-adrenal (HPA) axis function. We have previously shown rats that are overfed as neonates have exacerbated pro-inflammatory responses to immune challenge with lipopolysaccharide (LPS), in part by altering HPA axis responses, but how this
Rupali Sharma et al.
Journal of immunology (Baltimore, Md. : 1950), 202(7), 2131-2140 (2019-02-10)
Puberty is a critical period of development marked by sexual, immune, and neural maturation. Exposure to stress during this period can lead to enduring changes in brain functioning and in behavior; however, the underlying mechanisms and the programming effects of
Rose B Joachim et al.
Molecular systems biology, 14(5), e7998-e7998 (2018-05-19)
Attempts to develop drugs that address sepsis based on leads developed in animal models have failed. We sought to identify leads based on human data by exploiting a natural experiment: the relative resistance of children to mortality from severe infections
Rose Joachim et al.
Scientific reports, 7(1), 16541-16541 (2017-12-01)
Sepsis is a common and deadly syndrome in which a dysregulated host response to infection causes organ failure and death. The current lack of treatment options suggests that a new approach to studying sepsis is needed. Pre-pubertal children show a
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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