L3625
α-乳糖 一水合物
≥99% total lactose basis (GC)
别名:
β-D-Gal-(1→4)-α-D-Glc, 4-O-β- D -半乳糖基-α- D -葡萄糖, 乳糖
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关于此项目
经验公式（希尔记法）:
C12H22O11 · H2O
化学文摘社编号:
分子量:
360.31
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
产品名称
α-乳糖 一水合物, ≥99% total lactose basis (GC)
InChI
1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
SMILES string
[H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
InChI key
WSVLPVUVIUVCRA-KPKNDVKVSA-N
biological source
bovine milk
assay
≥99% total lactose basis (GC)
form
powder
impurities
≤0.05% Glucose
≤4% β-lactose
color
white to off-white
mp
219 °C ((426 °F ))
solubility
water: 100 mg/mL, clear, colorless
storage temp.
room temp
Quality Level
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Application
- 晶体尺寸是乳糖结晶的关键特性，影响奶粉的微观结构、表面化学和重构。本研究以α-乳糖一水合物为标准品，研究晶体尺寸如何影响奶粉的物理性质，这对于优化乳制品行业的生产工艺至关重要（Qi X et al., 2024）。
- 预测硫酸特布他林与α-乳糖一水合物的干粉吸入混合物的内聚和粘附颗粒相互作用强度。：探讨了α-乳糖一水合物作为赋形剂与硫酸特布他林一起在优化颗粒相互作用以增强可吸入治疗剂性能方面的关键作用（Ma CY et al., 2023）。
- 滚压颗粒制片剂的太赫兹时域光谱研究。：本研究利用α-乳糖一水合物检查药物片剂的性质，为影响药物递送系统的材料特性提供了深入见解（Anuschek M et al., 2023）。
Biochem/physiol Actions
α-乳糖是牛奶中主要的糖，也是新生哺乳动物通过母乳喂养获得的主要能量来源。它能被肠道乳糖酶（EC 3.2.1.108）消化，肠道乳糖酶是一种在新生儿中表达的酶。断奶后，这种酶的活性下降，导致成年哺乳动物出现乳糖不耐受。
乳糖是由一个半乳糖和一个葡萄糖分子经过缩合反应形成的二糖。乳糖是大多数物种乳汁中主要的糖，含量通常为2-8％。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Gwenola Le Dréan et al.
Nutrients, 11(9) (2019-08-24)
Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota
Helena Montanuy et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(12), 3044-3057 (2020-02-02)
Fanconi anemia rare disease is characterized by bone marrow failure and a high predisposition to solid tumors, especially head and neck squamous cell carcinoma (HNSCC). Patients with Fanconi anemia with HNSCC are not eligible for conventional therapies due to high
Johannes Gursch et al.
Journal of pharmaceutical sciences, 104(10), 3481-3489 (2015-07-07)
Over the last years, continuous manufacturing has created significant interest in the pharmaceutical industry. Continuous filtration at low flow rates and high solid loadings poses, however, a significant challenge. A commercially available, continuously operating, dynamic cross-flow filtration device (CFF) is
Sha Liu et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 132-142 (2015-07-30)
Co-administration of an inhaled corticosteroid and long acting beta agonist for chronic obstructive pulmonary disease has reduced mortality compared to either drug alone. This combination reduces exacerbations, hospitalization, emergency department visits and health care costs. A novel fixed-dose combination of
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