跳转至内容

关于应对近期政策变化的重要更新,请点击此处查看详情。

Merck
CN
所有图片(2)

主要文件

安全信息

L3414

Sigma-Aldrich

Monoclonal Anti-LAP2 (TMPO) antibody produced in mouse

~2 mg/mL, clone 6E10, purified immunoglobulin, buffered aqueous solution

别名:

Anti-CMD1T, Anti-Cardiomyopathy, dilated, 1T, included, Anti-Lamina Associated Polypeptide 2/Thymopoietin, Anti-TMPO, Anti-Thjymopoietin

登录查看公司和协议定价

选择尺寸

10 MG
¥416.52
25 G
¥664.50
100 G
¥897.36
1 KG
¥4,486.61

¥416.52


国内现货,预计发货时间2025年4月10日详情


获取大包装报价

选择尺寸

变更视图
10 MG
¥416.52
25 G
¥664.50
100 G
¥897.36
1 KG
¥4,486.61

About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

¥416.52


国内现货,预计发货时间2025年4月10日详情


获取大包装报价

生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

6E10, monoclonal

表单

buffered aqueous solution

分子量

antigen 25 kDa (ζ isoform)
antigen 38 kDa (γ isoform, singlet or doublet)
antigen 42 kDa (δ isoform)
antigen 45 kDa (ε isoform)
antigen 50 kDa (β isoform, singlet or doublet)
antigen 76 kDa (α isoform)

种属反应性

human

浓度

~2 mg/mL

技术

immunocytochemistry: suitable
microarray: suitable
western blot: 2-4 μg/mL using whole extract of cultured human chronic myelogenous leukemia K562 cells.

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
546585554995653438
mol wt

Mw ≥20000

mol wt

-

mol wt

-

mol wt

-

solubility

chloroform: soluble

solubility

chloroform: soluble

solubility

chlorinated solvents: soluble (including chloroform)

solubility

-

λmax

365 nm

λmax

-

λmax

381 nm

λmax

-

fluorescence

λex 374 nm; λem 417 nm in chloroform(lit.)

fluorescence

λex 387 nm; λem 420 nm in chloroform

fluorescence

λex 383 nm; λem 419 nm in chloroform

fluorescence

λex 406 nm; λem 490 nm in chloroform

OLED device performance

ITO/PEDOT:PSS/PVK/PFO/Ca

  • Color: blue
  • Max. Luminance: 102.3 Cd/m2
  • Max. EQE: 0.17 %

OLED device performance

-

OLED device performance

-

OLED device performance

-

一般描述

Monoclonal Anti-LAP2 (TMPO) (mouse IgG1 isotype) is derived from the 6E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide (amino acids 29-50) common to the N-terminus of all TMPOs. Thymopoietin β (TMPOβ)/lamina associated polypeptide 2 (LAP2) is a type II integral protein of the inner nuclear envelope (NE). In mammalian cells, six alternatively spliced TMPO isoforms, designated α, β, β′, γ, δ, ε, and ζ have been isolated and characterized. LAP2/TMPO proteins is highly conserved in mammals and Xenopus. The expression of the various TMPO isoforms is ubiquitous, with higher levels in proliferative tissues. It has four domains: a hydrophilic C-terminus domain, a hydrophobic transmembrane domain, a NE targeting and lamina-binding domain, and a chromatin binding domain. TMPOβ/LAP2 contains two putative p34cdc2 kinase phosphorylation sites.

免疫原

synthetic peptide corresponding to amino acids 29-50 common to the N-terminus of all human TMPOs (isoforms α, β, γ, δ, ε, and ζ).

应用

Monoclonal Anti-LAP2 (TMPO) antibody produced in mouse may be used in immunoblotting and immunocytochemistry.

生化/生理作用

Thymopoietin β (TMPOβ)/lamina associated polypeptide 2 (LAP2) is putatively involved in functional nuclear architecture and cell cycle control. TMPOβ/LAP2 plays a key role in nuclear envelope (NE) disassembly and reassembly during mitosis and linking chromatin to the NE in interphase. TMPOβ/LAP2 binds lamin B1 and chromosomes in a phosphorylation dependent manner. TMPOβ/LAP2, either together with germ-cell-less (GCL) or alone, can repress the transcriptional activity of the elongation factor 2-dimerization partner (E2F-DP) heterodimer. TMPOα/LAP2 has a role in regulating the dynamics of the nuclear lamina and this interaction is required for nuclear growth after mitosis.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品?  

试试我们的产品选型工具.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

    没有发现合适的版本?

    如果您需要特殊版本,可通过批号或批次号查找具体证书。

    已有该产品?

    在文件库中查找您最近购买产品的文档。

    访问文档库

    Review: Lamina-Associated Polypeptide 2 Isoforms and Related Proteins in Cell Cycle-Dependent Nuclear Structure Dynamics
    Dechat T, et al.
    Journal of Structural Biology, 129(2), 335-345 (2000)
    Detergent-salt resistance of LAP2alpha
    Dechat T, et al.
    The Embo Journal, 17(16), 4887-4902 (1998)

    我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

    联系客户支持