一般描述
凝集素（来自罗马蜗牛）是一种六聚体糖蛋白，分子量79 kDa。来源于罗马蜗牛的蛋白腺分泌。罗马蜗牛凝集素(HPA)对N-乙酰半乳糖胺(GalNAc)具有特异性。
应用
凝集素（来自罗马蜗牛）已用于标记生物素和吖啶，用于凝集素凝集试验。
生化/生理作用
凝集素（来自罗马蜗牛）作为卵周液组分可涂覆受精蛋进行保护。在蜗牛中具有抗菌性和免疫能力。罗马蜗牛凝集素(HPA)可凝集病原体。HPA还可作为癌症O糖基化异常的标志物。
HPA具有抗人A血型特异性，并且对末端N-乙酰基-α-D-半乳糖胺基残基具有亲和力。由亲和纯化的凝集素制备缀合物。
制备说明
通过改良的Hammarstrom/Kabat方法亲和纯化过。
分析说明
在报道中，凝集活性以μg/ml表示，用pH 6.8的磷酸盐缓冲液连续稀释1 mg/ml溶液进行测定。 该活性是指25℃孵育1小时后使2％人A型血红细胞混悬液凝集的最低浓度。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
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The FORS blood group system (originally recognized as the Apae phenotype) was discovered by sporadic activity against polyclonal anti-A reagents and activity against the lectin Helix pomatia. The extent of monoclonal anti-A reagent activity against the FORS1 antigen is serologically
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Ekin IH and Gurturk K
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Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients
Reily C, et al.
Biotechniques, 65(2), 71-77 (2018)
Biochemical and structural analysis of helix pomatia agglutinin a hexameric lectin with a novel fold
Sanchez JF, et al.
The Journal of biological chemistry, 281(29), 20171-20180 (2006)
Karin Säljö et al.
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