生物来源
Escherichia coli (O127:B8)
质量水平
形式
lyophilized powder
纯化方式
gel-filtration chromatography
杂质
<1% Protein
颜色
white to yellow cast
溶解性
water: soluble
运输
ambient
储存温度
2-8°C
正在寻找类似产品? 访问 产品对比指南
一般描述
该产品是从大肠杆菌血清型 O127:B8 中提取，并经凝胶过滤纯化。源菌株为ATCC 12740。该LPS血清型已经用于脓毒性休克的研究，并且可在大鼠肾小球masangial细胞中诱导小鼠巨噬细胞和PAF中的NOS合成。
应用
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
制备说明
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Eugene S Yim et al.
Journal of biomedical materials research. Part A, 91(3), 894-902 (2008-12-17)
Hydrogel polymers comprise a novel category of synthetic materials being investigated for use in cartilage replacement. One candidate compound, a poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) interpenetrating polymer network (IPN), was developed for use in corneal prostheses and was recently engineered for
Choon Kit Tang et al.
Biomaterials, 30(7), 1389-1400 (2008-12-09)
Receptor mediated gene delivery is an attractive non-viral method for targeting genetic material to specific cell types. We have previously utilized oxidized (OMPLL) and reduced mannan poly-L-lysine (RMPLL) to target DNA vaccines to antigen presenting cells and demonstrated that it
Gagan S Thangjam et al.
American journal of physiology. Lung cellular and molecular physiology, 310(10), L964-L974 (2016-04-03)
The ability of anti-heat shock protein 90 (Hsp90) drugs to attenuate NF-κB-mediated transcription is the major basis for their anti-inflammatory properties. While the molecular mechanisms underlying this effect are not clear, they appear to be distinct in human endothelial cells.
Mitsuaki Moriyama et al.
Neurochemical research, 41(11), 3138-3146 (2016-11-04)
The biomolecule acetate can be utilized for energy production, lipid synthesis, and several metabolic processes. Acetate supplementation reduces neuroglial activation in a model of neuroinflammation induced by intraventricular injection of lipopolysaccharide (LPS). To investigate the mechanisms underlying the anti-inflammatory effect
Evelin Painsipp et al.
PloS one, 6(6), e20719-e20719 (2011-06-16)
Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such an effect depends on mouse strain and
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门