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生物来源
Escherichia coli (O128:B12)
质量水平
表单
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to yellow cast
溶解性
water: soluble
运输
ambient
储存温度
2-8°C
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相关类别
一般描述
该产物是从大肠杆菌血清型O128:B12中通过苯酚提取得到。源菌株为CDC 2440-69。
应用
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征性成分。LPS及其脂质A部分可通过Toll样受体4（TLR4）刺激先天免疫系统细胞，TLR4是Toll样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
制备说明
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Ziqiao Yuan et al.
Acta pharmaceutica Sinica. B, 10(5), 861-877 (2020-06-13)
Previously, we proposed a new perspective of triptolide (TP)-associated hepatotoxicity: liver hypersensitivity upon lipopolysaccharide (LPS) stimulation. However, the mechanisms for TP/LPS-induced hepatotoxicity remained elusive. The present study aimed to clarify the role of LPS in TP/LPS-induced hepatotoxicity and the mechanism
Elsa Youngsteadt et al.
PloS one, 10(11), e0142031-e0142031 (2015-11-05)
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Ester Zito et al.
Molecular cell, 40(5), 787-797 (2010-12-15)
Endoplasmic reticulum (ER) oxidation 1 (ERO1) transfers disulfides to protein disulfide isomerase (PDI) and is essential for oxidative protein folding in simple eukaryotes such as yeast and worms. Surprisingly, ERO1-deficient mammalian cells exhibit only a modest delay in disulfide bond
Stephen B Pruett et al.
BMC immunology, 10, 49-49 (2009-09-22)
Previous reports indicate that ethanol, in a binge drinking model in mice, inhibits the production of pro-inflammatory cytokines in vivo. However, the inhibition of signaling through TLR4 has not been investigated in this experimental model in vivo. Considering evidence that
Yijing Su et al.
Journal of applied toxicology : JAT, 34(12), 1436-1442 (2014-10-22)
Isoniazide (INH) is a classic antituberculosis drug associated with clinical idiosyncratic drug-induced liver injury. It has been hypothesized that the interaction between a drug and modest inflammation results in a decreased threshold for drug toxicity. In this study, we tested
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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