生物来源
Escherichia coli (O26:B6)
质量水平
无菌性
γ-irradiated
产品线
BioXtra
表单
lyophilized powder
纯化方式
gel-filtration chromatography
技术
cell culture | mammalian: suitable
杂质
<5% Protein (Lowry)
溶解性
H2O: 5 mg/mL, slightly hazy
储存温度
2-8°C
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应用
来自 大肠杆菌026:B6的脂多糖用于引发人PBMC、小鼠骨髓树突细胞 和大鼠星形胶质细胞分泌细胞因子。
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
LPS是大多数革兰氏阴性细菌细胞壁的主要成分。它是一种高免疫原性抗原，可增强对可溶性抗原的免疫应答。LPS也是小鼠、兔、鸡、牛、仓鼠和人的骨髓源B淋巴细胞的特异性促分裂原。
制备说明
脂多糖以冻干的γ--辐射粉末形式提供。复溶时，向样品瓶（1 mg）中加1 ml无菌平衡盐溶液或组织培养基，轻轻涡旋，直至粉末溶解。可使用无菌平衡盐溶液或组织培养基将复溶产品进一步稀释至所需工作浓度。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
David Gozal et al.
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Sleep disordered breathing in children is associated with severity-dependent increases in excessive daytime sleepiness (EDS). TNF-alpha is an inflammatory cytokine that has been implicated in EDS. Since, at any given level of apnea-hypopnea index, there is significant variability in EDS
Ø Salvesen et al.
Journal of neuroinflammation, 14(1), 106-106 (2017-05-24)
The cellular prion protein (PrP In order to explore putative roles for PrP All LPS-treated goats displayed clinical signs of sickness behavior, which were of significantly (p < 0.01) longer duration in animals without PrP Our data suggest that PrP
Asad Ali et al.
The Journal of steroid biochemistry and molecular biology, 180, 73-80 (2018-02-07)
Emerging evidence suggests that maternal or developmental vitamin D (DVD) deficiency is a risk factor for Autism Spectrum Disorders. A well-established association has also been found between gestational infection and increased incidence of autism. Placenta mediates the maternal immune response
S Ménard et al.
Gut, 53(6), 821-828 (2004-05-13)
Probiotic bacteria have a beneficial effect on intestinal inflammation. In this study, we have examined the effect of lactic acid and commensal Gram positive (+) bacteria conditioned media (CM) on tumour necrosis factor alpha (TNF-alpha) release and the mechanisms involved.
Peta J O'Connell et al.
Blood, 107(3), 1010-1017 (2005-10-15)
Adaptive immunity is triggered at the immune synapse, where peptide-major histocompatibility complexes and costimulatory molecules expressed by dendritic cells (DCs) are physically presented to T cells. Here we describe transmission of the inflammatory monoamine serotonin (5-hydroxytryptamine [5-HT]) between these cells.
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