产品名称
脂多糖 来源于伤寒沙门氏菌, purified by gel-filtration chromatography
biological source
bacterial (Salmonella typhosa)
form
lyophilized powder
purified by
gel-filtration chromatography
impurities
<1% Protein
color
white to faint yellow
solubility
water: soluble
storage temp.
2-8°C
Quality Level
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Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS 及其脂质 A 部分通过 Toll 样受体 4（TLR4）刺激先天免疫系统的细胞，TLR4 是 Toll 样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
General description
本品是从伤寒沙门氏菌中提取，经凝胶过滤纯化而得。源菌株是ATCC 10749。
Preparation Note
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Malick M Gibani et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(8), 1265-1273 (2018-09-27)
Shedding of Salmonella Typhi or Paratyphi in the stool or urine leads to contamination of food or water, which is a prerequisite for transmission of enteric fever. Currently, there are limited data on the effect of vaccination or prior exposure
Thomas C Darton et al.
PLoS neglected tropical diseases, 10(8), e0004926-e0004926 (2016-08-18)
Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious
Malick M Gibani et al.
PLoS neglected tropical diseases, 14(10), e0008783-e0008783 (2020-10-21)
Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood. Prior exposure is thought to confer partial, but incomplete, protection against subsequent attacks
Claire S Waddington et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 58(9), 1230-1240 (2014-02-13)
Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi infection. Until 1974, a human challenge model advanced understanding of typhoid and was
Thomas C Darton et al.
Frontiers in microbiology, 8, 1794-1794 (2017-10-04)
Current diagnostic tests for typhoid fever, the disease caused by
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
相关内容
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
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