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Merck
CN

L2261

毛花苷C

≥97% (TLC)

别名:

C 级镧, 地高辛 C, 异丙酰胺, 毛花苷C

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关于此项目

经验公式（希尔记法）:
C49H76O20
化学文摘社编号:
17575-22-3
分子量:
985.12
NACRES:
NA.25
PubChem Substance ID:
24896307
UNSPSC Code:
12352201
EC Number:
241-546-1
MDL number:
MFCD00869432

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产品名称

毛花苷C, ≥97% (TLC)

InChI key

JAYAGJDXJIDEKI-PTGWOZRBSA-N

InChI

1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1

SMILES string

C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(C)=O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)[C@H](CC[C@@H]7[C@@H]6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5

assay

≥97% (TLC)

form

powder

color

white

storage temp.

−20°C

Quality Level

100

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相关类别

Application


  • 肝细胞癌中的强心苷敏化：研究表明，通过涉及活性氧生成、p38MAPK 激活、线粒体转化和自噬调节的机制，毛花苷C增强了肝细胞癌细胞对TRAIL诱导的细胞凋亡的敏感性（Rasheduzzaman et al., 2019）。

  • 未分化人胚胎干细胞的消除：研究表明毛花苷C选择性地消除未分化人胚胎干细胞，揭示了其在确保干细胞治疗安全性中的潜在用途（Lin et al., 2017）。

Other Notes

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - STOT RE 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN2652
BCCK3455
BCCF9273
BCCF2230
BCCB8247

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P E Santos et al.
Toxicon : official journal of the International Society on Toxinology, 28(2), 215-224 (1990-01-01)
The effects of crotoxin, isolated from the venom of the South American rattlesnake, Crotalus durissus terrificus, were investigated on isolated guinea pig hearts, perfused with Locke solution, by the Langendorff method. The cardiac beats and the electrocardiogram were simultaneously registered
P Sandouk et al.
Presse medicale (Paris, France : 1983), 15(27), 1273-1275 (1986-07-05)
Digoxin, digitoxin and acetyldigitoxin are the most widely prescribed of cardiotonic glycosides. Analytical exploration can be performed by a single assay when only one compound is prescribed or by multiple assays in cases of imprecise prescription or when several glycosides
Christian E Badr et al.
Neuro-oncology, 13(11), 1213-1224 (2011-07-16)
Human glioblastoma (GBM) cells are notorious for their resistance to apoptosis-inducing therapeutics. We have identified lanatoside C as a sensitizer of GBM cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell death partly by upregulation of the death receptor 5.
T Imamura et al.
Circulation, 71(1), 11-16 (1985-01-01)
We sought to determine whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mm Hg, which decreased central venous pressure
A Takeshita et al.
Japanese circulation journal, 50(7), 671-674 (1986-07-01)
We examined whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mmHg which decreased central venous pressure (CVP) but did
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