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一般描述
牛乳脂蛋白脂酶(LPL)是一种糖蛋白。它以同型二聚体形式存在，由两个N-连接的寡糖组成。具有热不稳定性。
应用
牛乳脂蛋白脂酶已用于：
- 研究脂蛋白脂酶作为补充剂对乳腺癌细胞MDA-MB-231中DiI(1,1′-双十八烷基-3,3,3′-四甲基吲哚碳菁高氯酸盐)-极低密度脂蛋白(VLDL)摄取的影响
- 处理人脑微血管内皮细胞(HBMEC)以脂解富含三酰甘油的脂蛋白(TGRL)
- 检测脂蛋白脂酶对正常人星形胶质细胞基因表达的影响
生化/生理作用
牛乳脂蛋白脂酶(LPL)具有最高的脂解活性。它与酪蛋白胶束有关。LPL调节甘油三酯利用度，具有位点特异性。脂酶通常催化甘油三酯的脂裂解，尤其是甘油三酯sn-1和sn-3位的脂肪酸。
单位定义
以 p -硝基苯丁酸酯为底物，在 37°C、pH 7.2 条件下，1 个单位每分钟将释放 1.0 nmol p -硝基苯酚。
外形
用 3.8 M 硫酸铵、0.02 MTris HCl (pH 8.0) 混悬
制备说明
亲和纯化
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Biochemistry, Lipoprotein Lipase
Pirahanchi Y, et al.
StatPearls [Internet] (2023)
Leslie E Lupien et al.
Journal of lipid research, 61(2), 205-218 (2019-12-07)
We previously described the expression of CD36 and LPL by breast cancer (BC) cells and tissues and the growth-promoting effect of VLDL observed only in the presence of LPL. We now report a model in which LPL is bound to
Y Ikeda et al.
Nihon rinsho. Japanese journal of clinical medicine, 52(12), 3146-3152 (1994-12-01)
We describe molecular and physiological properties of human lipoprotein lipase (LPL) based on recent advanced knowledges. Human LPL is a lipolytic glycoprotein enzyme synthesized by extrahepatic tissues, mainly adipocytes, and its gene is located on chromosome 8p22 with 10 exons
Hnin Hnin Aung et al.
Journal of lipid research, 57(6), 955-968 (2016-04-19)
Dysfunction of the cerebrovasculature plays an important role in vascular cognitive impairment (VCI). Lipotoxic injury of the systemic endothelium in response to hydrolyzed triglyceride-rich lipoproteins (TGRLs; TGRL lipolysis products) or a high-fat Western diet (WD) suggests similar mechanisms may be
F de Beer et al.
Arteriosclerosis, thrombosis, and vascular biology, 20(7), 1800-1806 (2000-07-15)
The apolipoprotein E2 (Lys146-->Gln) variant is associated with a dominant form of familial dysbetalipoproteinemia. Heterozygous carriers of this variant have elevated levels of plasma triglycerides, cholesterol, and apolipoprotein E (apoE). It was hypothesized that the high amounts of triglycerides in
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Lipid Induced Insulin Resistance
脂肪组织中的胰岛素耐受性减少了循环游离脂肪酸的摄入，并增加了脂肪酶对储存甘油三酯的水解。了解与胰岛素耐受性相关的激素、细胞因子和脂肪因子。
以硫酸铵悬浮液形式提供的酶的使用指南
Instructions for working with enzymes supplied as ammonium sulfate suspensions
实验方案
Lipoprotein lipase (LPL) hydrolyzes triglycerides associated with VLDL.
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