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Merck
CN
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文件

安全信息

L2023

Sigma-Aldrich

亮肽素 三氟乙酸盐

powder, ≥90% (HPLC)

别名:

Acetyl-Leu-Leu-Arg-al 三氟乙酸盐

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About This Item

经验公式（希尔记法）:
C20H38N6O4 · xC2HF3O2
CAS号:
147385-61-3
分子量:
426.55 (free base basis)
MDL编号:
MFCD00133458
UNSPSC代码:
12352202
PubChem化学物质编号:
329817397
NACRES:
NA.77

product name

亮肽素 三氟乙酸盐, ≥90% (HPLC), microbial

生物来源

microbial

质量水平

200

检测方案

≥90% (HPLC)

形式

powder

溶解性

H2O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)

储存温度

−20°C

SMILES字符串

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1

InChI key

WUHGBZVQELGOMH-FRKSIBALSA-N

相关类别

生化/生理作用

丝氨酸和半胱氨酸蛋白酶抑制剂。抑制纤溶酶、胰蛋白酶、木瓜蛋白酶、钙蛋白酶和组织蛋白酶B。不抑制胃蛋白酶、组织蛋白酶A和D、凝血酶或α-糜蛋白酶。有效浓度为10-100 μM。已有许多研究使用亮抑酶肽来预防因听觉过度刺激或耳毒性抗生素庆大霉素引起的听力损失。(耳蜗毛细胞的丧失被认为是由钙蛋白酶介导的。)

分析说明

由于在溶液中形成互变异构异构体，亮抑酶肽在 HPLC 上产生多个峰。大多数污染肽是外消旋亮抑酶肽。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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