L1795
Anti-PLAGL1 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-LOT-1, Anti-Lost on transformation 1, Anti-PLAL1, Anti-Pleiomorphic adenoma-like protein 1, Anti-Tumor supressor ZAC
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所有图片(2)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 0.5-1 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human PLAGL1
western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human PLAGL1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PLAGL1(5325)
一般描述
The gene PLAGL1 (pleiomorphic adenoma-like protein 1), PLAGL2 and PLAG1 form a subfamily of PLAG family of zinc finger proteins that recognize DNA and RNA. The three members share similarity at the amino-terminal, but are functionally different, varying in their DNA binding capacities. The gene is mapped to human chromosome 6q24.2, a region implicated in several cancers.
特异性
Anti-PLAGL1 (C-terminal) specifically recognizes human PLAGL1.
应用
Anti-PLAGL1 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
生化/生理作用
PLAGL1 gene expression is downregulated in a methylation-sensitive manner. PLAGL1 is an imprinted gene that mediates an imprinted gene network that plays an important role in embryonic growth control.
The maternally-imprinted gene, PLAGL1 (pleiomorphic adenoma-like protein 1), functions as an oncogene as well as a tumor suppressor depending on the cell context. It has been found to exhibit anti-proliferative properties and regulate apoptosis and cell-cycle arrest via p53.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
新产品
Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
Varrault A, et al.
Developmental Cell, 11(5), 711-722 (2006)
Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.
Kas K
The Journal of Biological Chemistry, 273, 23026-23032 (1998)
The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities.
Hensen K
Cancer Research, 62, 1510-1517 (2002)
Anne-Lise Peille et al.
PloS one, 8(11), e80741-e80741 (2013-11-22)
Soft tissue sarcomas (STS) are rare, complex tumors with a poor prognosis. The identification of new prognostic biomarkers is needed to improve patient management. Our aim was to determine the methylation status of the 118 CpG sites in the PLAGL1
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