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Merck
CN

L1751

Sigma-Aldrich

亚油酸乙酯

≥99%

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别名:
亚麻油酸乙酯
线性分子式:
CH3(CH2)3(CH2CH=CH)2(CH2)7COOC2H5
CAS号:
分子量:
308.50
Beilstein:
1727827
EC 号:
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.25

生物来源

plant oil (safflower)

质量水平

检测方案

≥99%

形式

liquid

折射率

n20/D 1.455 (lit.)

bp

224 °C/17 mmHg (lit.)

密度

0.876 g/mL at 25 °C (lit.)

官能团

ester

脂质类型

omega FAs

运输

ambient

储存温度

−20°C

SMILES字符串

CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC

InChI

1S/C20H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-4-2/h8-9,11-12H,3-7,10,13-19H2,1-2H3/b9-8-,12-11-

InChI key

FMMOOAYVCKXGMF-MURFETPASA-N

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应用


  • Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride.: This study explores the formulation of a self-microemulsifying drug delivery system (SMEDDS) using ethyl linoleate as a key component to improve the oral bioavailability of berberine hydrochloride. The findings indicate a significant increase in bioavailability, demonstrating the potential of SMEDDS in enhancing the absorption of poorly water-soluble drugs (Zhu et al., 2013).

  • Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis.: The research includes the use of ethyl linoleate in the study of liver metabolomics to understand the biochemical effects of alcohol dosing. Ethyl linoleate′s role in nonpolar metabolite profiling provides insights into liver function and the metabolic impacts of alcohol consumption (Loftus et al., 2011).

  • Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.: This article reports on the utilization of ethyl linoleate in a self-microemulsifying drug delivery system to enhance the bioavailability of silymarin. The study shows improved absorption and bioavailability of silymarin, highlighting the effectiveness of ethyl linoleate in drug delivery applications (Wu et al., 2006).

生化/生理作用

从三角紫叶酢浆草中分离的亚油酸乙酯能够在小鼠B16黑素瘤细胞中抑制毛喉素诱导的黑色素生成和酪氨酸酶活性。这种抗黑色素生成作用是通过抑制cAMP产生来介导的。
在检测酒精滥用时,亚油酸乙酯可用作定量脂肪酸乙酯(FAEE)的参考物质。可以使用亚油酸乙酯作为乙酰胆碱酯酶(AChE)抑制剂进行研究。

WGK

WGK 1

闪点(°F)

235.4 °F

闪点(°C)

113 °C

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析证书(COA)

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Jonathan Kissling et al.
Phytotherapy research : PTR, 19(11), 984-987 (2005-12-01)
In a search for potential acetylcholinesterase (AChE) inhibitors, the ethanol extract of the bulbs of Crinum x powellii (Amaryllidaceae) was found to demonstrate a marked inhibition of this enzyme. Using a bio-guided isolation strategy, linoleic acid ethyl ester has been
Abdulsallam Bakdash et al.
Analytical and bioanalytical chemistry, 396(7), 2469-2477 (2010-02-11)
Fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) were determined in 602 meconium samples in a maternal health evaluation study for detection of gestational alcohol consumption. A validated headspace solid phase microextraction method in combination with GC-MS was used
Janine R Hutson et al.
Alcohol (Fayetteville, N.Y.), 45(2), 193-199 (2010-08-14)
Fatty acid ethyl esters (FAEEs) are nonoxidative metabolites of ethanol, and elevated levels of FAEE in meconium are a useful biomarker for heavy prenatal alcohol exposure. FAEE in meconium has been recommended as useful and cost-effective for universal screening for
Fritz Pragst et al.
Therapeutic drug monitoring, 30(2), 255-263 (2008-03-28)
The retrospective detection of alcohol consumption during pregnancy is an important part of the diagnosis of the fetal alcohol syndrome. A promising way to solve this problem can be the determination of fatty acid ethyl esters (FAEE) or/and ethyl glucuronide
Ho-Seok Kwak et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(21), 1871-1874 (2010-07-08)
This paper reports the development and validation of an improved assay for quantitation of fatty acid ethyl esters (FAEEs) in human meconium using liquid chromatography/tandem mass spectrometry (LC-MS/MS). FAAEs (ethyl laurate, ethyl myristate, ethyl palmitate, ethyl palmitoleate, ethyl stearate, ethyl

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