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About This Item
经验公式（希尔记法）:
C20H38N6O4 · HCl
CAS号:
分子量:
463.01
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
product name
亮肽素 盐酸盐, microbial, ≥70% (HPLC)
生物来源
microbial
质量水平
检测方案
≥70% (HPLC)
形式
powder
溶解性
water: 50 mg/mL, clear, colorless to yellow
储存温度
−20°C
SMILES字符串
Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
InChI
1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
InChI key
OQQYPQNFLLAILR-UHFFFAOYSA-N
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生化/生理作用
丝氨酸和半胱氨酸蛋白酶抑制剂。抑制纤溶酶、胰蛋白酶、木瓜蛋白酶、钙蛋白酶和组织蛋白酶 B。不抑制胃蛋白酶、组织蛋白酶 A 和 D、凝血酶或 α-糜蛋白酶。有效浓度 10-100 μM。已有许多研究使用亮肽素预防由声过度刺激或耳毒性抗生素庆大霉素引起的听力丧失。（耳蜗毛细胞的丢失被认为是由钙蛋白酶介导的。）
分析说明
Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
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