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一般描述
来自 小麦 的凝集素是36kDa的二聚体糖蛋白。它属于几丁质结合蛋白家族。凝集素的糖基化前体在内质网中合成。
应用
小麦来源凝集素已用于：
- 与N-羟基琥珀酰亚胺（NHS）染料偶联
- 抑制核输入
- 抑制人类宫颈癌HeLa和SiHa细胞的核孔
生化/生理作用
WGA 不具有血型特异性，但具有与 N-乙酰基-β-D-葡糖胺残基和 N-乙酰基-β-D-葡糖胺低聚物的亲和性。WGA 不含蛋白结合糖。
具有四个结合位点的小麦凝集素对N-乙酰基-d-葡糖胺和N-乙酰基-d-神经氨酸（唾液酸）残基具有特异性。凝集素也起杀真菌剂的作用。它们还具有抗营养作用。
其他说明
高度纯化
制备说明
由亲和纯化凝集素制备偶联物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Plant lectins: occurrence, biochemistry, functions and applications
Rudiger H and Gabius HJ
Glycoconjugate Journal, 18, 589-613 (2001)
Tsung-Lin Tsai et al.
International journal of nanomedicine, 7, 5215-5234 (2012-10-17)
Gold nanoparticles modified with the nuclear localization signal from simian virus 40 large T antigen (GNP-PEG/SV40) accumulate on the cytoplasmic side of the nuclear membrane in HeLa cells. Accumulation of GNP-PEG/SV40 around the nucleus blocks nucleocytoplasmic transport and prevents RNA
Pengfei Zhang et al.
Chemical science, 13(43), 12760-12768 (2022-12-16)
Exosome analysis is a promising tool for clinical and biological research applications. However, detection and biomarker quantification of exosomes is technically challenging because they are small and highly heterogeneous. Here, we report an optical approach for imaging exosomes and quantifying
Nuclear localization of Tob is important for regulation of its antiproliferative activity
Kawamura-Tsuzuku J, et al.
Oncogene, 23, 6630-6630 (2004)
Super-multiplex vibrational imaging
Wei L, et al.
Nature, 544, 465-465 (2017)
商品
Find the right lectin for your research with our lectin selection guide, organized by lectin source/species, carbohydrate specificity, blood group specificity, and more.
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