所有图片(1)
别名:
(5S,6R,15S)-三羟基-(7E,9E,11Z,13E)-二十碳四烯酸
经验公式（希尔记法）:
C20H32O5
CAS号:
分子量:
352.47
EC 号:
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
形式
ethanol solution
质量水平
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
InChI
1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
InChI key
IXAQOQZEOGMIQS-SSQFXEBMSA-N
生化/生理作用
脂蛋白A4（LXA4）由花生四烯酸合成，是一种内源性脂氧合酶衍生的类花生酸介体。它是一种有效的人蛋白激酶C激活剂。它抑制自然杀伤细胞的细胞毒性。LXA4调节免疫系统和炎症。在大脑中，它调节神经元信号传导和慢波睡眠。LXA4与大麻素受体结合。LXA4在子宫内膜和生殖功能的维持中起关键作用。LXA4的消耗有助于囊性纤维化（CF）的病理生理。
包装
氩气包装。
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
55.4 °F
闪点(°C)
13 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
Stephanie G Dakin et al.
Scientific reports, 7(1), 11009-11009 (2017-09-10)
The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with chronic tendinopathy. Interleukin(IL)-1β treatment markedly
The role of lipoxin A 4 in endometrial biology and endometriosis.
Canny GO and Lessey BA
Mucosal Immunology, 6(3), 439-439 (2013)
K C Nicolaou et al.
Biochimica et biophysica acta, 1003(1), 44-53 (1989-05-15)
Addition of (15S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid (15-HETE) and the ionophore A23187 (2.5 microM) to human neutrophils led to the formation of both lipoxin A4 and lipoxin B4 as well as a novel 5,6,15-trihydroxyeicosatetraenoic acid. The new compound was identified using an improved
Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.
Liu X, et al.
Scientific Reports, 7(1), 7100-7100 (2017)
Ioannis Kourtzelis et al.
Nature immunology, 20(1), 40-49 (2018-11-21)
Resolution of inflammation is essential for tissue homeostasis and represents a promising approach to inflammatory disorders. Here we found that developmental endothelial locus-1 (DEL-1), a secreted protein that inhibits leukocyte-endothelial adhesion and inflammation initiation, also functions as a non-redundant downstream
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