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一般描述
作为脂质运载蛋白家族的成员，β-乳球蛋白（βLg）是162个氨基酸的小蛋白质，分子量为∼18,400Da。它具有八链β-桶（链A-H），其后面是三转α-螺旋和最终 β-链（链I），其形成二聚化界面的一部分。
来自奶牛的牛奶含有蛋白质 β-乳球蛋白（BLG）。它天然存在于许多遗传变异体中，最普遍的牛变体是BLG A和BLG B。
应用
来自牛奶的β-乳球蛋白用于测试对牛′s 奶过敏的儿童过敏原反应性 CD4 + CD25 + 调节性 T细胞。它还用于测试 Tween 20 从油 - 水和空气 - 水界面的β-乳球蛋白的竞争性置换。
其他说明
含 β-乳球蛋白 A 和 B，可通过色谱法分离。
质量
可能不含叶酸结合蛋白；不推荐用于叶酸分析。
制备说明
结晶
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A Heinzmann et al.
International archives of allergy and immunology, 120(4), 280-286 (2000-01-21)
beta-Lactoglobulin (BLG) represents one of the major allergens causing cow's milk allergy (CMA) - a disease with a wide spectrum of clinical symptoms. The aim of this study was to evaluate sequential B cell epitopes of BLG by the Pin-ELISA
Isabella Pali-Schöll et al.
Clinical and translational allergy, 12(2), e12125-e12125 (2022-02-17)
Growing up on a cattle farm and consuming raw cow's milk protects against asthma and allergies. We expect a cattle-specific protein as active component in this farm effect. Dust was collected from cattle and poultry stables and from mattresses of
Rachana Pathak et al.
European biophysics journal : EBJ, 51(4-5), 335-352 (2022-05-17)
Amyloid crystals, a form of ordered protein aggregates documented relatively recently, have not been studied as extensively as amyloid fibres. This study investigates the formation of amyloid crystals with low frequency ultrasound (20 kHz) using β-lactoglobulin, as a model protein for
André C Dumetz et al.
Biophysical journal, 94(2), 570-583 (2007-12-28)
The aggregates and gels commonly observed during protein crystallization have generally been considered disordered phases without further characterization. Here their physical nature is addressed by investigating protein salting-out in ammonium sulfate and sodium chloride for six proteins (ovalbumin, ribonuclease A
Nicholas A Smith et al.
Brain, behavior, and immunity, 95, 122-141 (2021-03-12)
A number of studies have reported comorbidity of food allergies with various neuropsychiatric disorders, such as anxiety, depression, attention-deficit hyperactivity disorder, and autism. However, inconsistent results across clinical studies have left the association between food allergy and behavioral disorders inconclusive.
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