Monoclonal Anti-KSR (Kinase Suppressor of Ras) antibody produced in rat

Kinase Suppressor of Ras (KSR) is a positive effector of Ras signalling pathway. Initially discovered in Drosophila and C. elegans, the KSR family of proteins is structurally similar but distinct from the Raf Family. In response to Ras activation, KSR translocates from the cytoplasm to the plasma membrane and may act as a scaffolding protein to assemble a MAPK signalling complex. KSR interacts with Raf-1, MEK1/2 and ERK1/2 and this interaction is required for a signalling cascade downstream of Ras. Thus KSR plays an important role in survival, proliferation, differentiation, growth and transformation of cells. KSR mediates Ras-dependent signals that are required for neuronal differentiation and functioning of central nervous system
Monoclonal Anti-KSR specifically reacts with mouse KSR (~100 kDa).

recombinant KSR fragment (amino acids 118-248) from mouse.

Anti-KSR is suitable for immunoblotting at a working concentration of 0.5-1.0 μg/mL using human 293T cells expressing mouse KSR. The antibody may be used for immunocytochemistry and protein microarray applications.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Purified from culture supernatant of hybridoma cells grown in a bioreactor.

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