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重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
比活
97-131 nmol/min·mg
分子量
~93 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PRKCZ(5590)
生化/生理作用
PKCζ (protein kinase C ζ) is a atypical PKC and works independent of Ca2+ and diacylglycerol. It is involved in MAPK (mitogen-activated protein kinase)-induced nuclear factor κ B activation. It also stabilizes DNA mismatch-repair proteins, participates in laeukemic cell differentiation, cell migration and chemotaxis. PKCζ have tumour suppressor as well as oncogenic properties. Upregulation of PKCζ causes apoptosis in ovarian carcinoma cells. On the other hand, absence of PKCζ decreases tumorigenic activity in a colon cancer mouse model.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
S J Kim et al.
Biochemical and biophysical research communications, 237(2), 336-339 (1997-08-18)
To examine whether multiple protein kinase C (PKC) isoforms could interact or crosstalk, phorbol ester-insensitive atypical PKC (aPKC) zeta isoform was overexpressed in NIH3T3 cells, and the cells were stimulated with phorbol ester to activate diacylglycerol-dependent conventional (cPKC) and novel
A Romanelli et al.
Molecular and cellular biology, 19(4), 2921-2928 (1999-03-19)
p70 S6 kinase (p70S6K) is an important regulator of cell proliferation. Its activation by growth factor requires phosphorylation by various inputs on multiple sites. Data accumulated thus far support a model whereby p70S6K activation requires sequential phosphorylations at proline-directed residues
S A Hartsink-Segers et al.
Leukemia, 29(2), 304-311 (2014-07-06)
Both tumour suppressor and oncogenic functions have been ascribed to the atypical zeta isoform of protein kinase C (PKCζ), whereas its constitutively active form PKMζ is almost exclusively expressed in the brain where it has a role in long-term memory.
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