质量水平
检测方案
≥98% (HPLC)
形式
solid
溶解性
DMSO: 20 mg/mL
soluble
储存温度
2-8°C
SMILES字符串
CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)[C@]34C[C@H]5C[C@H](C[C@@H]3C5)C4
InChI
1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-
InChI key
PJBFVWGQFLYWCB-OYEQCZOJSA-N
生化/生理作用
KW-3902 is an A1 adenosine receptor antagonist and is over 800 fold more selective for an A1 receptor versus the A2A receptor.
特点和优势
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Christopher M O'Connor et al.
Circulation. Heart failure, 4(6), 724-732 (2011-09-09)
Cardiac troponin T (cTnT) elevation is common and is a predictor of outcomes in patients with acute heart failure (AHF). The degree and progression of cTnT release during hospitalization of patients with AHF is unclear. We evaluated the incidence of
Beth Davison Weatherley et al.
Journal of cardiac failure, 16(1), 25-35 (2010-02-04)
Current treatment for acute decompensated heart failure (ADHF) is associated with incomplete resolution of symptoms and signs, recurrent symptoms of heart failure in-hospital and after discharge and high mortality. Studies have consistently demonstrated an association between worsening renal function in
Gad Cotter et al.
Journal of cardiac failure, 14(8), 631-640 (2008-10-18)
Rolofylline, an adenosine A(1) receptor antagonist, facilitates diuresis and preserves renal function in patients with acute heart failure (AHF) with renal impairment. Although not powered around any specific hypothesis, this pilot study was designed to identify an efficacious dose while
John R Teerlink et al.
Drug safety, 35(3), 233-244 (2012-02-22)
Adenosine exerts actions in multiple organ systems, and adenosine receptors are a therapeutic target in many development programmes. The aim of this analysis was to evaluate the safety of rolofylline, an adenosine A(1)-receptor antagonist, in patients with acute heart failure.
Adriaan A Voors et al.
Journal of the American College of Cardiology, 57(19), 1899-1907 (2011-05-07)
This study sought to assess the effects of rolofylline on renal function in patients with acute heart failure (AHF) and renal dysfunction randomized in PROTECT (Placebo-Controlled Randomized Study of the Selective A(1) Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With
商品
We offers many products related to adenosine receptors for your research needs.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门