K3269

抗-Kindlin-2 兔抗

Name: 抗-Kindlin-2 兔抗
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

包含抗-Pleckstrin同源结构域， C家族1成员, 抗-FERMT2, 抗-Fermitin家族同源物2, 抗-KIND2, 抗-MIG2, 抗-PLEKHC1, 抗-UNC112, 抗-UNC112B, 抗-丝裂原诱导基因2蛋白

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

indirect immunofluorescence
western blot

Species reactivity:

mouse, rat, canine, human

Citations:

Technique(s):

indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells
western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells

Uniprot accession no.:

Q96AC1

主要文件

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产品名称

抗-Kindlin-2 兔抗, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~72 kDa

species reactivity

mouse, rat, canine, human

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells
western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells

UniProt accession no.

Q96AC1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... FERMT2(10979)
mouse ... Fermt2(218952)
rat ... Fermt2(289992)

Application

抗-kindlin-2兔抗可用于western blotting。

Biochem/physiol Actions

Kindlin-2 可作为粘附斑蛋白（ focal adhesion protein ），通过促进基因组不稳定性控制乳腺癌进展。作为整联蛋白相互作用蛋白，Kindlin-2在整联蛋白的激活和整联蛋白介导的细胞-细胞外基质（ECM）相互作用中起关键作用。Kindlin-2的表达与肝细胞癌（HCC）和胰管腺癌（PDAC）患者的不良预后有关。因此，kindlin-2被认为是HCC和PDAC患者的潜在生物标志物。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

抗-kindlin-2抗体可识别人、小鼠、大鼠和狗中的kindlin-2。Kindlin-2，也称为费米铁蛋白家族成员2（FERMT2）或含pleckstrin同源结构域家族C成员1（PLEKHC1），由对应于人类染色体14q22.1的基因编码。Kindlin-2是kindlin蛋白家族的一员，具有普遍存在的表达模式。

Other Notes

为了在不同的技术和制备中获得最佳结果，我们建议通过效价测试确定最佳的工作浓度。

Physical form

溶于含有15 mM叠氮化钠的0.01 M磷酸盐缓冲液（pH 7.4）。

Preparation Note

如需连续使用，可在2-8°C下保存一个月。对于长期储存，可将工作浓度的分装品冷冻。不建议反复冻融。如果长期储存时出现轻微混浊，使用前通过离心澄清溶液。如果在12小时内未使用，则应丢弃工作稀释样品。

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000490137

0000430839

0000364960

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Sorting nexin 17 prevents lysosomal degradation of ?1 integrins by binding to the ?1-integrin tail.

Bottcher RT, et al.

Nature Cell Biology, 14, 584-592 (2012)

Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling

Wu X, et al.

International Journal of Molecular Medicine, 37, 436-444 (2016)

Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice.

Bing Li et al.

Science China. Life sciences, 62(2), 225-234 (2018-11-22)

Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary

HIF-1α interacts with Kindlin-2 and influences breast cancer elasticity: A study based on shear wave elastography imaging.

Xiaowei Xue et al.

Cancer medicine, 9(14), 4971-4979 (2020-05-22)

Breast cancer was the most frequent and the second most deadly cancer in women in 2018 in China; thus, early diagnosis of breast cancer is important. Studies have reported that tissue stiffness promotes cancer progression through increased collagen or fibrosis.

Kindlin-2: a novel prognostic biomarker for patients with hepatocellular carcinoma.

Yong-Sheng Ge et al.

Pathology, research and practice, 211(3), 198-202 (2015-01-27)

The association of aberrant expression of Kindlin-2 with tumor progression has been reported in recent years. The purpose of this study was to investigate the expression of Kindlin-2 in hepatocellular carcinoma (HCC), and to evaluate its clinical and prognostic significance.

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抗-Kindlin-2 兔抗

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

concentration

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Disclaimer

General description

Other Notes

Physical form

Preparation Note

安全信息

存储类别

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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