形式
buffered aqueous solution
质量水平
比活
≥5 units/mg protein
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... KLK1(3816)
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一般描述
Kallikrein肽酶属于15个高度保守的胰蛋白酶或胰凝乳蛋白酶家庭的成员。血浆激肽释放酶（PK）是一种来源于血浆前激肽释放酶的丝氨酸蛋白酶，也是一种在血液循环中含量较高的酶原。KLKB1基因位于人染色体4q35.2上。
应用
从人血浆中提取的激肽释放酶已用于：
- 培养人肝癌细胞系
- 研究其对来自脑膜炎奈瑟氏菌的奈瑟球菌肝素结合抗原（NHBA）的裂解作用
- 肽酶抑制分析
生化/生理作用
血浆激肽释放酶（PK）参与缓激肽的合成，可维持血液代谢物水平和高血压。它还参与凝血因子XII的激活，促进炎症和内源性凝血途径。PK控制心血管系统中的蛋白水解级联反应，如激肽酶激肽系统、肾素血管紧张素系统、纤维蛋白溶解系统和补体旁路等。它参与胰高血糖素样肽-1（GLP-1）和神经肽Y（NPY） 的裂解，这表明血浆激肽释放酶可能会影响代谢和糖尿病。
单位定义
一个酶活性单位是指在pH 8.7、25°C条件下，每分钟将1.0 μMNα-苯甲酰基-L-精氨酸乙酯（BAEE）水解为Nα-苯甲酰基-L-精氨酸和乙醇所需的酶量。
外形
溶于20 mM Tris-HCl (pH 7.8)和100 mM NaCl的溶液中。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Elisa Pantano et al.
PloS one, 14(8), e0203234-e0203234 (2019-08-02)
Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein of Neisseria meningitidis and a component of the Bexsero vaccine. NHBA is characterized by the presence of a highly conserved Arg-rich region involved in binding to heparin and heparan sulphate proteoglycans
Xueqing Xu et al.
Nucleic acids research, 37(22), 7381-7393 (2009-10-13)
A subtelomeric region, 4q35.2, is implicated in facioscapulohumeral muscular dystrophy (FSHD), a dominant disease thought to involve local pathogenic changes in chromatin. FSHD patients have too few copies of a tandem 3.3-kb repeat (D4Z4) at 4q35.2. No phenotype is associated
Allen P Kaplan et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 104(3), 193-204 (2010-04-10)
To review the mechanisms by which bradykinin is generated in hereditary angioedema (HAE) (C1 inhibitor deficiency), including the role of human plasma proteins and endothelial cells. Published articles in reviewed journals that address (1) the fundamentals of bradykinin formation, (2)
R Dellalibera-Joviliano et al.
Scandinavian journal of immunology, 71(4), 292-297 (2010-04-14)
In the present study, we evaluated the kinin system components in the plasma of patients with systemic lupus erythematosus exhibiting mucocutaneous lesions. Fifteen women with active cutaneous lupus (P) and 15 normal healthy women (C) were studied. Low molecular (LKg)
D Kolte et al.
British journal of pharmacology, 162(7), 1639-1649 (2010-12-24)
Kallikrein acts on high molecular weight kininogen (HK) to generate HKa (cleaved HK) and bradykinin (BK). BK exerts its effects by binding to B(2) receptors. The activation of B(2) receptors leads to the formation of tissue plasminogen activator, nitric oxide
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