K2389
红藻氨酸 一水合物
From Digenea simplex, ≥98% (HPLC), Kainate glutamate receptor agonist, powder
别名:
2-羧甲基-3-异丙烯基脯氨酸
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关于此项目
经验公式（希尔记法）:
C10H15NO4 · H2O
化学文摘社编号:
分子量:
231.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
红藻氨酸 一水合物, ≥98% (HPLC), from Digenea simplex
SMILES string
O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
InChI
1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
InChI key
FZNZRJRSYLQHLT-SLGZUKMRSA-N
biological source
Digenea simplex
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Quality Level
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Application
红藻氨酸一水合物曾被用于：
- 作为惊厥剂诱发小鼠癫痫发生和癫痫。
- 体外刺激 内毛细胞上螺旋神经节神经元的兴奋性毒性创伤。
- 诱导大鼠癫痫发作模型。
- 诱导成年雄性 Wistar 大鼠癫痫持续状态。
Biochem/physiol Actions
离子型谷氨酸受体形成离子通道，并传导 Na + 和 K + 通量。受体具有激动剂结合站点，当激动剂与受体结合后，受体构象更改。红藻氨酸门控通道参与谷氨酸诱导的兴奋性突触后神经元电位。
红藻氨酸-水合物是一种激动剂，属于红藻类离子性谷氨酸受体，在 体内 诱导癫痫发作和神经退行性变，被用于诱导啮齿类动物实验性癫痫，并研究兴奋性诱导神经元凋亡的机制。
红藻氨酸盐类离子性谷氨酸受体激动剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Isabel San Martín Molina et al.
Frontiers in neuroscience, 16, 944432-944432 (2022-08-16)
Non-invasive magnetic resonance imaging (MRI) methods have proved useful in the diagnosis and prognosis of neurodegenerative diseases. However, the interpretation of imaging outcomes in terms of tissue pathology is still challenging. This study goes beyond the current interpretation of in
Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures
Gotzsche CR, et al.
Neurobiology of Disease, 45(1), 288-296 (2012)
Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures
Woldbye David PD, et al.
Brain, 133(9), 2778-2788 (2010)
Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice
Rantala J, et al.
Epilepsy & Behavior : E&B, 42, 117-128 (2015)
Antti M Airaksinen et al.
Epilepsia, 53(7), 1245-1253 (2012-06-14)
To investigate how kainic acid-induced epileptiform activity is related to hemodynamic changes probed by blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI). Epileptiform activity was induced with kainic acid (KA) (10 mg/kg, i.p.), and simultaneous fMRI at 7 Tesla
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