跳转至内容
Merck
CN

K2015

Sigma-Aldrich

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

别名:

SF 2370

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C27H21N3O5
CAS号:
分子量:
467.47
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

生物来源

Nonomuraea longicatena

质量水平

方案

>98%

表单

solution

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

基因信息

human ... NTRK1(4914)
rat ... Prkca(24680)

正在寻找类似产品? 访问 产品对比指南

生化/生理作用

K-252a 还是Trk(酪氨酸激酶)受体的特异性抑制剂,可选择性阻断神经生长因子的效应。较低浓度的 K-252a 可作为神经保护性化合物,促进原代神经元培养物存活。K-252a 通过抑制 Cdc2 和 Cdc25c,诱导细胞周期停滞和凋亡。K-252a 可改善 SCID 小鼠-人类皮肤模型中的牛皮癣状况,并可抑制与急性胰腺炎相关的机械超敏反应和神经肽上调。

特点和优势

《受体分类和信号转导》手册的 MetPKC 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

外形

以 0.2μm 过滤的 1 mM 二甲亚砜 (DMSO) 溶液形式提供。

相关产品

产品编号
说明
价格

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Z Pawlowska et al.
Journal of neurochemistry, 60(2), 678-686 (1993-02-01)
The phosphorylation of surface proteins by ecto-protein kinase has been proposed to play a role in mechanisms underlying neuronal differentiation and their responsiveness to nerve growth factor (NGF). PC12 clones represent an optimal model for investigating the mode of action
Ruslana Bryk et al.
Bioorganic & medicinal chemistry letters, 21(13), 4108-4114 (2011-06-03)
We report the identification of new, structurally diverse inhibitors of interferon-induced, double-stranded RNA-activated protein kinase (PKR) using a combined experimental and computational approach. A training set with which to build a predictive statistical model was generated by screening a set
Siba P Raychaudhuri et al.
The Journal of investigative dermatology, 122(3), 812-819 (2004-04-17)
The peripheral nervous system, in addition to its sensory and motor functions, can induce a local inflammatory response known as neurogenic inflammation. This phenomenon plays a critical role in several inflammatory diseases, e.g., asthma, atopy, rheumatoid arthritis, psoriasis, and ulcerative
L S Chin et al.
Cancer investigation, 17(6), 391-395 (1999-08-06)
The indole carbazole K252a has been shown in previous studies to inhibit the platelet-derived growth factor signal transduction pathway in gliomas. Because K252a has nonspecific effects on protein kinase function, we studied its effect on cyclin-dependent kinases (CDK) and cell
M A Glicksman et al.
Journal of neurochemistry, 64(4), 1502-1512 (1995-04-01)
The organic molecule K-252a promoted cell survival, neurite outgrowth, and increased choline acetyltransferase (ChAT) activity in rat embryonic striatal and basal forebrain cultures in a concentration-dependent manner. A two- to threefold increase in survival was observed at 75 nM K-252a

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门