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Sigma-Aldrich

α-酮戊二酸钠 钠盐

BioUltra

别名:

2-氧代戊二酸 单钠盐, 2-氧化戊二酸 单钠盐, 2-酮戊二酸钠 一元

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About This Item

线性分子式:
HOOCCH2CH2COCOONa
CAS号:
22202-68-2
分子量:
168.08
Beilstein:
4597521
EC 号:
244-836-6
MDL编号:
MFCD00064196
UNSPSC代码:
12352204
PubChem化学物质编号:
24896216
NACRES:
NA.32

产品线

BioUltra

质量水平

200

方案

≥98% (perchloric acid titration)

表单

powder

杂质

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

溶解性

H2O: 0.5 M, clear, colorless

痕量阴离子

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

痕量阳离子

Al: ≤0.0005%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

储存温度

2-8°C

SMILES字符串

[Na+].OC(=O)CCC(=O)C([O-])=O

InChI

1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);/q;+1/p-1

InChI key

MOTOGHHLNTXPTI-UHFFFAOYSA-M

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相关类别

应用

α-酮戊二酸钠盐已用于人犬尿氨酸氨基转移酶II（KAT-II）的抑菌谱测定。

生化/生理作用

α-酮戊二酸是L-谷氨酸的前体。
α-酮戊二酸是TCA循环中的关键中间体。它还可与细胞内释放的氮结合，从而在防止氮超载方面发挥重要作用。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000369172
0000369172
0000289556
0000289555
0000289555

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Structure-based design of irreversible human KAT II inhibitors: Discovery of new potency-enhancing interactions
Tuttle JB, et al.
ACS Medicinal Chemistry Letters, 4(1), 37-40 (2012)
Amino Acids in Therapy: A Guide to the Therapeutic Application of Protein Constituents, 34-34 (1985)
N A Smirnova et al.
Biochemistry. Biokhimiia, 77(10), 1108-1119 (2012-11-20)
This review describes the catalytic mechanism, substrate specificity, and structural peculiarities of alpha-ketoglutarate dependent nonheme iron dioxygenases catalyzing prolyl hydroxylation of hypoxia-inducible factor (HIF). Distinct localization and regulation of three isoforms of HIF prolyl hydroxylases suggest their different roles in
Piotr Dobrowolski et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 556-561 (2012-12-12)
Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely
Michael E Jung et al.
The Journal of organic chemistry, 77(23), 11002-11005 (2012-11-21)
Oxidative cleavage of cycloalkene-1-carboxylates, made from the corresponding carboxylic acids, and subsequent oxidation of the resulting ketoaldehyde afforded the important 1-monoesters of 2-ketoalkanedioic acids. Thus ozonolysis of octyl cyclobutene-1-carboxylate followed by sodium chlorite oxidation afforded the 1-monooctyl 2-ketoglutarate. This is
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