所有图片(1)
About This Item
经验公式（希尔记法）:
C43H60N2O12
CAS号:
分子量:
796.94
EC 号:
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
生物来源
Streptomyces collinus
质量水平
表单
powder
颜色
yellow
溶解性
methanol: 1.90-2.10 mg/mL, clear, yellow
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
protein synthesis | interferes
储存温度
−20°C
SMILES字符串
CCC(C(=O)NC\C=C\C=C(/C)C(OC)C(C)C1OC(\C=C\C=C\C=C(/C)C(=O)C2=C(O)C=CNC2=O)C(O)C1O)C3(O)OC(\C=C\C=C\C)C(C)(C)C(O)C3O
InChI
1S/C43H60N2O12/c1-9-11-13-21-31-42(6,7)38(50)39(51)43(54,57-31)28(10-2)40(52)44-23-17-16-19-26(4)36(55-8)27(5)37-35(49)34(48)30(56-37)20-15-12-14-18-25(3)33(47)32-29(46)22-24-45-41(32)53/h9,11-22,24,27-28,30-31,34-39,48-51,54H,10,23H2,1-8H3,(H,44,52)(H2,45,46,53)/b11-9+,14-12+,17-16+,20-15+,21-13+,25-18+,26-19+
InChI key
HMSYAPGFKGSXAJ-DSMBXYKSSA-N
一般描述
Chemical structure: polyene
应用
Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.
生化/生理作用
Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-alpha-decarboxylase, KirD, which is involved in the biosynthesis of the precursor beta-alanine.
Kristina J Laiple et al.
The Journal of antibiotics, 62(8), 465-468 (2009-07-18)
Mikel Valle et al.
The EMBO journal, 21(13), 3557-3567 (2002-07-03)
During the elongation cycle of protein biosynthesis, the specific amino acid coded for by the mRNA is delivered by a complex that is comprised of the cognate aminoacyl-tRNA, elongation factor Tu and GTP. As this ternary complex binds to the
Ewa M Musiol et al.
Chemistry & biology, 18(4), 438-444 (2011-04-26)
In the biosynthesis of complex polyketides, acyltransferase domains (ATs) are key determinants of structural diversity. Their specificity and position in polyketide synthases (PKSs) usually controls the location and structure of building blocks in polyketides. Many bioactive polyketides, however, are generated
K Mikulík et al.
Biochemical and biophysical research communications, 289(2), 434-443 (2001-11-22)
Protein kinase associated with ribosomes of streptomycetes phosphorylates 11 ribosomal proteins. Phosphorylation activity of protein kinase reaches its maximum at the end of exponential phase of growth. When (32)P-labeled cells from the end of exponential phase of growth were transferred
Mikel Valle et al.
Science (New York, N.Y.), 300(5616), 127-130 (2003-04-05)
Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an approximately 300-nucleotide-long molecule that functions as both transfer RNA (tRNA) and mRNA. Translation then switches from the defective message to a short open reading frame on tmRNA
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门