生物来源
human epidermis
质量水平
检测方案
≥90% (SDS-PAGE)
形式
urea solution
技术
ELISA: suitable
UniProt登记号
储存温度
2-8°C
基因信息
human ... KRT1(3848)
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一般描述
角蛋白是上皮组织的标志性中间纤维蛋白。在人类中，角蛋白分为I型和II型。约有54个基因编码角蛋白。角蛋白1（KRT1）基因被定位到人类染色体12q13.13上。它是头发、皮肤和指甲的主要成分。
应用
人表皮角蛋白已用于：
- 在固相抗体芯片中作为分析物和交叉反应剂用于测定选择系数
- 作为细胞外基质(ECM)蛋白标准品进行体外蛋白降解分析
- 作为酶联免疫吸附测定(ELISA)的标准品
生化/生理作用
角蛋白对于上皮细胞和组织的机械稳定性和完整性非常重要。一些角蛋白还具有调节功能，并可参与细胞内信号转导途径，例如对压力的保护、伤口愈合和细胞凋亡。这组多样化的细胞骨架支架蛋白可形成中等细丝网络，其为维持皮肤完整性的角质形成细胞提供了结构支持。角蛋白基因的表达通常受分层鳞状上皮细胞内表皮细胞分化的调节。
外形
溶于 8 M 尿素、50 mM Tris、0.1 M β-巯基乙醇和 0.1% 叠氮化钠，pH 8.4
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Christian Mozet et al.
Anticancer research, 33(6), 2415-2424 (2013-06-12)
The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with
N O Ku et al.
The Journal of cell biology, 143(7), 2023-2032 (1998-12-29)
Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18
Francesca Angiero et al.
Anticancer research, 33(6), 2673-2677 (2013-06-12)
The adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin, composed of odontogenic epithelium and characterized by slow but progressive growth. We report a rare case of AOT in an 18-year-old, who presented with a palpable bony-hard swelling
Next-generation sequencing detection and characterization of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma
Banerjee S, et al.
Experimental Dermatology, 24(2), 152-155 (2015)
Jyh-Hong Lee et al.
Journal of biomedical optics, 14(1), 014008-014008 (2009-03-05)
Atopic dermatitis (AD) is characterized by hyperkeratosis of epidermis and fibrosis within dermis in chronic skin lesions. Thus far, the histology of skin lesions has been evaluated only by examination of excised specimens. A noninvasive in vivo tool is essential
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