质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
violet
溶解性
DMSO: ≥10 mg/mL
H2O: <2 mg/mL
储存温度
room temp
SMILES字符串
Oc1ccc(CCNc2ccc(NCCc3ccc(O)cc3)c4C(=O)c5ccccc5C(=O)c24)cc1
InChI
1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2
InChI key
UUJHFIBEJJLZBF-UHFFFAOYSA-N
生化/生理作用
JFD00244 is a SIRT (sirtuin, human silent information regulator) inhibitor.
特点和优势
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
新产品
Anu J Tervo et al.
Journal of medicinal chemistry, 47(25), 6292-6298 (2004-11-30)
Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in the cell cycle. To date, some small molecular inhibitors of
Anu J Tervo et al.
Journal of medicinal chemistry, 49(24), 7239-7241 (2006-11-28)
A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Two of these
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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