推荐产品
质量水平
检测方案
≥97% (HPLC)
形式
film (colorless)
颜色
off-white to beige
溶解性
DMSO: >2 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
C[C@H]1C[C@@H](C)\C=C(C)\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c4ccc(O)cc4
InChI
1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
InChI key
GQWYWHOHRVVHAP-DHKPLNAMSA-N
应用
Jasplakinolide已用于体内分析其对鸡胚坐骨神经导向作用的影响。还用于处理对照细胞来抑制其肌动蛋白动态。
生化/生理作用
Jasplakinolide 是一种肌动蛋白特异性试剂，可促进肌动蛋白聚合，稳定肌动蛋白丝。 在体外 ，茉莉醛通过刺激肌动蛋白丝成核，强效诱导肌动蛋白聚合，与鬼笔环肽竞争肌动蛋白结合 (Kd = 15 nM)。 体内 研究发现，Jasplakinolide 可破坏肌动蛋白丝，诱导单体肌动蛋白聚合成无定形质量，其确切机制尚未确定。Jasplakinolide 不同于其他肌动蛋白稳定剂，它具有细胞渗透性。这种肽具有杀真菌、杀虫和抗增殖活性，可用于研究由肌动蛋白聚合和解聚介导的细胞过程，如细胞粘附、运动、内吞和囊泡分选和释放。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
The developmental and genetic basis of `clubfoot? in the peroneal muscular atrophy mutant mouse
Collinson J M, et al.
Development, 145(3), 160093-160093 (2018)
Jelena Dinic et al.
Biochimica et biophysica acta, 1828(3), 1102-1111 (2012-12-19)
The relationship between ordered plasma membrane nanodomains, known as lipid rafts, and actin filaments is the focus of this study. Plasma membrane order was followed in live cells at 37°C using laurdan and di-4-ANEPPDHQ to report on lipid packing. Disrupting
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
Jose T Thaiparambil et al.
Molecular and cellular biology, 32(16), 3203-3217 (2012-06-13)
The proper orientation of the mitotic spindle is essential for mitosis; however, how these events unfold at the molecular level is not well understood. AMP-activated protein kinase (AMPK) regulates energy homeostasis in eukaryotes, and AMPK-null Drosophila mutants have spindle defects.
Jeffery C Noro et al.
Chemistry & biodiversity, 9(10), 2077-2095 (2012-10-20)
The discovery of novel natural products for drug development relies heavily upon a rich biodiversity, of which the marine environment is an obvious example. Marine natural product research has spawned several drugs and many other candidates, some of which are
P Preira et al.
Lab on a chip, 13(1), 161-170 (2012-11-14)
The deformability of circulating leukocytes plays an important role in the physiopathology of several diseases like sepsis or acute respiratory distress syndrome (ARDS). We present here a microfluidic method for the passive testing, sorting and separating of non-adherent cell populations
商品
包含β-肌动蛋白、α-微管蛋白和波形蛋白用于细胞骨架结果蛋白活细胞分析的高滴度慢病毒颗粒。
High titer lentiviral particles including beta-actin, alpha-tubulin and vimentin used for live cell analysis of cytoskeleton structure proteins.
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